Development and application of DNA hydrogels in biosensing: current status and future implications

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dc.contributor.authorChen, Zhuo
dc.contributor.authorMao, Kang
dc.contributor.authorXue, Jiaqi
dc.contributor.authorFeng, Rida
dc.contributor.authorZhang, Kuankuan
dc.contributor.authorSu, Junxia
dc.contributor.authorDu, Wei
dc.contributor.authorRan, Jiabing
dc.contributor.authorYang, Changying
dc.contributor.authorYang, Zhugen
dc.contributor.authorZhang, Hua
dc.date.accessioned2025-05-07T15:11:55Z
dc.date.available2025-05-07T15:11:55Z
dc.date.freetoread2025-05-07
dc.date.issued2025-06-01
dc.date.pubOnline2025-04-18
dc.description.abstractAs emerging biopolymer materials, DNA hydrogels quickly respond to external stimuli to specifically recognize DNA through base pairing and have become widely used in the field of biosensors. Unlike traditional biosensing strategies, biosensors based on DNA hydrogels are highly specific, programmable and degradable. In this work, based on the advantages and wide application of DNA hydrogels in the field of biosensors, the progress of DNA hydrogel biosensors is systematically summarized in terms of the types of DNA hydrogels, detection principles and biosensor device integration. First, the types of DNA hydrogels used in biosensors are briefly introduced. Next, we thoroughly demonstrate the detection principles of DNA hydrogel biosensors; the detection principles depend on the recognition elements, signal elements, and transduction types of the DNA hydrogel used in the biosensor. In particular, we demonstrate the great potential of integrated devices and techniques used in DNA hydrogel biosensors, such as microfluidics and portable devices. Finally, the challenges and future development of DNA hydrogels in biosensing are discussed. This work can be used as a reference for research on biosensing analysis using DNA hydrogels.
dc.description.journalNameMicrochemical Journal
dc.description.sponsorshipThe authors acknowledge the Youth Innovation Promotion Association CAS (2023415) and the Guizhou Provincial Science and Technology Projects (Qiankehe Platform Talents-GCC [2023] 046).
dc.identifier.citationChen Z, Mao K, Xue J, et al. (2025) Development and application of DNA hydrogels in biosensing: current status and future implications. Microchemical Journal, Volume 213, June 2025, Article number 113664
dc.identifier.elementsID672911
dc.identifier.issn0026-265X
dc.identifier.paperNo113664
dc.identifier.urihttps://doi.org/10.1016/j.microc.2025.113664
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23864
dc.identifier.volumeNo213
dc.languageEnglish
dc.language.isoen
dc.publisherElsevier
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0026265X25010185?via%3Dihub
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDNA hydrogel
dc.subjectBiosensor
dc.subjectAptamer
dc.subjectFluorescence
dc.subjectColorimetry
dc.titleDevelopment and application of DNA hydrogels in biosensing: current status and future implications
dc.typeArticle
dc.type.subtypeReview
dcterms.dateAccepted2025-04-15

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