Atoxigenic isolates of Aspergillus flavus effectively reduce cyclopiazonic acid in a sorghum-based matrix under simulated abiotic stress conditions

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dc.contributor.authorSharma, Vanshika
dc.contributor.authorCervini, Carla
dc.contributor.authorVerheecke-Vaessen, Carol
dc.contributor.authorBandyopadhyay, Ranajit
dc.contributor.authorMedina, Angel
dc.contributor.authorOrtega-Beltran, Alejandro
dc.contributor.authorMagan, Naresh
dc.date.accessioned2025-05-23T13:33:34Z
dc.date.available2025-05-23T13:33:34Z
dc.date.freetoread2025-05-23
dc.date.issued2025-05-15
dc.date.pubOnline2025-05-15
dc.description.abstractMaize, groundnut, and sorghum are important staple crops in several countries, but are prone to mycotoxin contamination. In the tropics and subtropics, Aspergillus flavus frequently contaminates those crops with aflatoxins and, sometimes, with cyclopiazonic acid (CPA). However, some genotypes cannot produce one or both toxins. In various countries, atoxigenic isolates of A. flavus are formulated into biocontrol products for field use to outcompete aflatoxin producers. The products effectively limit aflatoxin but their utility to reduce CPA remains unexplored. The abilities of four atoxigenic isolates (AF-) from Burkina Faso to control CPA by an isolate with high capacity to produce aflatoxins (AF+) and CPA was tested in co-inoculations at varying ratios (100+, 75+/25-, 50+/50-, 25+/75-, 100-), under simulated abiotic stress conditions. Experiments were conducted on 2% sorghum-based media at 0.95 and 0.90 water activity (aw), at 30°C and 37°C, for 12 days. CPA was quantified using LC-MS/MS. CPA concentrations gradually decreased as the proportion of atoxigenic isolates increased, with effectiveness varying depending on the environmental conditions.
dc.description.journalNameLetters in Applied Microbiology
dc.description.sponsorshipWe are grateful to donors that provided funds to conduct the research: Royal Government of Norway through the Climate Smart Agricultural Technologies (CSAT; MLI-17/0008 and NER-260 17/0005) for Mali and Niger; and CGIAR Agriculture for Nutrition and Health (A4NH) Research Program and One CGIAR’s Plant Health and Rapid Response to Protect Food Security and Livelihoods Initiative (Plant Health Initiative) through contributions of various donors to the CGIAR Trust Fund: www.cgiar.org/funders/.
dc.format.extentpp. xx-xx
dc.format.mediumPrint-Electronic
dc.identifier.citationSharma V, Cervini C, Verheecke-Vaessen C, et al., (2025) Atoxigenic isolates of Aspergillus flavus effectively reduce cyclopiazonic acid in a sorghum-based matrix under simulated abiotic stress conditions. Letters in Applied Microbiology, Available online 15 May 2025
dc.identifier.eissn1472-765X
dc.identifier.elementsID673290
dc.identifier.issn0266-8254
dc.identifier.issueNoahead-of-print
dc.identifier.urihttps://doi.org/10.1093/lambio/ovaf072
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23920
dc.identifier.volumeNoahead-of-print
dc.languageEnglish
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.publisher.urihttps://academic.oup.com/lambio/advance-article-abstract/doi/10.1093/lambio/ovaf072/8132917?redirectedFrom=fulltext
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject30 Agricultural, Veterinary and Food Sciences
dc.subject3004 Crop and Pasture Production
dc.subjectInfectious Diseases
dc.subjectabiotic factors
dc.subjectbiocontrol
dc.subjectbioprotectant
dc.subjectgrains
dc.subjectmycotoxins
dc.subjectresilience
dc.subjectMicrobiology
dc.subject3009 Veterinary sciences
dc.subject3107 Microbiology
dc.subject3207 Medical microbiology
dc.titleAtoxigenic isolates of Aspergillus flavus effectively reduce cyclopiazonic acid in a sorghum-based matrix under simulated abiotic stress conditions
dc.typeArticle
dc.type.subtypeJournal Article
dcterms.coverageEngland
dcterms.dateAccepted2025-05-09

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