Functional evaluation and testing of a newly developed Teleost's Fish Otolith derived biocomposite coating for healthcare

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dc.contributor.authorMontañe, Nerly D.
dc.contributor.authorCarreño, Heider
dc.contributor.authorEscobar, Patricia
dc.contributor.authorEstupiñán, Hugo A.
dc.contributor.authorPeña, Darío Y.
dc.contributor.authorGoel, Saurav
dc.contributor.authorEndrino, José L.
dc.date.accessioned2020-01-17T16:43:53Z
dc.date.available2020-01-17T16:43:53Z
dc.date.issued2019-01-14
dc.description.abstractPolymers such as polycaprolactone (PCL) possess biodegradability, biocompatibility and affinity with other organic media that makes them suitable for biomedical applications. In this work, a novel biocomposite coating was synthesised by mixing PCL with layers of calcium phosphate (hydroxyapatite, brushite and monetite) from a biomineral called otolith extracted from Teleost fish (Plagioscion Squamosissimus) and multiwalled carbon nanotubes in different concentrations (0.5, 1.0 and 1.5 g/L). The biocomposite coating was deposited on an osteosynthesis material Ti6Al4V by spin coating and various tests such as Fourier transformation infrared spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), scratch tests, MTT reduction cytotoxicity, HOS cell bioactivity (human osteosarcoma) by alkaline phosphatase (ALP) and fluorescence microscopy were performed to comprehensively evaluate the newly developed biocoating. It was found that an increase in the concentration of carbon nanotube induced microstructural phase changes of calcium phosphate (CP) leading to the formation of brushite, monetite and hydroxyapatite. While we discovered that an increase in the concentration of carbon nanotube generally improves the adhesion of the coating with the substrate, a certain threshold exists such that the best deposition surfaces were obtained as PCL/CP/CNT 0.0 g/L and PCL/CP/CNT 0.5 g/L.en_UK
dc.identifier.citationMontañez ND, Carreño H, Escobar P, et al., (2020) Functional evaluation and testing of a newly developed Teleost's Fish Otolith derived biocomposite coating for healthcare. Scientific Reports, Volume 10, January 2020, Article number 258en_UK
dc.identifier.cris25677672
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-019-57128-w
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/14952
dc.language.isoenen_UK
dc.publisherNature Research (part of Springer Nature)en_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCalcium phosphateen_UK
dc.subjectmultiwalled carbon nanotubesen_UK
dc.subjectfish otolithen_UK
dc.subjectpolycaprolactoneen_UK
dc.titleFunctional evaluation and testing of a newly developed Teleost's Fish Otolith derived biocomposite coating for healthcareen_UK
dc.typeArticleen_UK

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