Browsing by Author "Wang, Baojun"
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Item Open Access Paper-based devices for rapid diagnosis and wastewater surveillance(Elsevier, 2022-09-06) Pan, Yuwei; Mao, Kang; Hui, Qinxin; Wang, Baojun; Cooper, Jonathan; Yang, ZhugenInfectious diseases are a global concern for public health resulting in high rates of infection with subsequent health and socio-economic impacts through resulting morbidity and mortality. The emergence of such diseases has motivated researchers to develop cost-effective, rapid and sensitive analytical methods and devices to better understand the transmission routes of infections within populations. To this end, rapid and low-cost diagnosis and testing devices for infectious diseases are attracting increasing amounts of attention, e.g., through using paper-based analytical devices (PADs). In this paper, the recent development of PADs is critically reviewed both for the diagnosis of inviduals and population health, by using devices for testing wastewater. Finally, the review also focuses on PADs for the analysis of bacteria and viruses in wastewater, together with a discussion on thee future development of PADs for rapid diagnosis and wastewater surveillance.Item Embargo Rapid enzymatic assays for fecal contamination in aquatic environment: challenges, advances and prospects(Elsevier, 2024-05-22) Yuan, Xiaofei; Glidle, Andrew; Yang, Zhugen; Wang, BaojunRoutine monitoring of sanitation and hygiene to identify fecal contamination in aquatic environments is an effective means to prevent threatening disease transmission. Compared to immunological or genetic methods performed in a central lab, enzymatic assays are considered simple, quick, cost-effective and thus promising for in-field (near) real-time detection. However, the long detection time for mildly polluted samples is a major obstacle to its deployment as an early warning system. Here, the challenges faced by the assays in real environmental sample measurements are summarized, followed by the current status of their field applications. Furthermore, the likelihood and ways are discussed for significant assay improvements using state-of-the-art synthetic biology technologies. Rapid advances in synthetic biology such as various new enabling tools for precise biomolecular manipulation and cell-free expression systems have great potential to address the present bottlenecks of the enzymatic assays, paving the way for better early warning strategies and performance.