Molecular biology interventions for activity improvement and production of industrial enzymes

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dc.contributor.authorBhatia, Shashi Kant
dc.contributor.authorVivek, Narisetty
dc.contributor.authorKumar, Vinod
dc.contributor.authorChandel, Neha
dc.contributor.authorThakur, Meenu
dc.contributor.authorKumar, Dinesh
dc.contributor.authorYang, Yung-Hun
dc.contributor.authorPugazhendhi, Arivalagan
dc.contributor.authorKumar, Gopalakrishnan
dc.date.accessioned2021-01-20T17:55:05Z
dc.date.available2021-01-20T17:55:05Z
dc.date.issued2020-12-24
dc.description.abstractMetagenomics and directed evolution technology have brought a revolution in search of novel enzymes from extreme environment and improvement of existing enzymes and tuning them towards certain desired properties. Using advanced tools of molecular biology i.e. next generation sequencing, site directed mutagenesis, fusion protein, surface display, etc. now researchers can engineer enzymes for improved activity, stability, and substrate specificity to meet the industrial demand. Although many enzymatic processes have been developed up to industrial scale, still there is a need to overcome limitations of maintaining activity during the catalytic process. In this article recent developments in enzymes industrial applications and advancements in metabolic engineering approaches to improve enzymes efficacy and production are revieweden_UK
dc.identifier.citationBhatia SK, Vivek N, Kumar V, et al., (2020) Molecular biology interventions for activity improvement and production of industrial enzymes. Bioresource Technology, Volume 324, March 2021, Article number 124596en_UK
dc.identifier.issn0960-8524
dc.identifier.urihttps://doi.org/10.1016/j.biortech.2020.124596
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16214
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFusion proteinen_UK
dc.subjectDirected evolutionen_UK
dc.subjectMetagenomicsen_UK
dc.subjectPharmaceuticalen_UK
dc.subjectCosmeticen_UK
dc.subjectEnzymeen_UK
dc.titleMolecular biology interventions for activity improvement and production of industrial enzymesen_UK
dc.typeArticleen_UK

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