Development of new fluorescent silica and multifunctional nanoparticles for bio-imaging and diagnostics

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dc.contributor.advisorMorgan, Sarah
dc.contributor.advisorTothill, Ibtisam E.
dc.contributor.authorLemelle, Arnaud
dc.date.accessioned2012-06-26T10:51:26Z
dc.date.available2012-06-26T10:51:26Z
dc.date.issued2011-03
dc.description.abstractSilica nanoparticles are effective fluorophore carriers with high potential in imaging, diagnostics, and therapy. The particles are resistant to drastic change of environmental conditions (pH, temperature etc. and insulate the dyes so as to protect them from photobleaching. Silica chemistry is also versatile and affords an easy modification of the particle composition and surface to integrate targeting ligands or to integrate other nanoparticles. Regardless of their advantages, there exists a lack of dye diversity in the literature that is connected to a low affinity for potential tools for biology and medicineThis thesis describes the development of an alternative method for the synthesis of fluorescent silica nanoparticles and their modification to incorporate iron oxide and gold. cont/d.en_UK
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/7279
dc.language.isoenen_UK
dc.publisherCranfield Universityen_UK
dc.rights© Cranfield University 2011. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright owner.en_UK
dc.subjectNanomedicineen_UK
dc.subjectimagingen_UK
dc.subjectsol-gelen_UK
dc.subjectnanoparticlesen_UK
dc.subjectsilicaen_UK
dc.subjectiron oxide,en_UK
dc.subjectgolden_UK
dc.titleDevelopment of new fluorescent silica and multifunctional nanoparticles for bio-imaging and diagnosticsen_UK
dc.typeThesis or dissertationen_UK
dc.type.qualificationlevelDoctoralen_UK
dc.type.qualificationnamePhDen_UK

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PhD, EngD and MSc by research theses (Cranfield Health)