Cross-linking of γ-cyclodextrin using non-toxic polyethylene glycol spacer units

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dc.contributor.authorDossi, Eleftheria
dc.contributor.authorBolton, Morgan
dc.contributor.authorKister, Guillaume
dc.contributor.authorAfsar, Ashfaq
dc.date.accessioned2021-09-23T11:58:32Z
dc.date.available2021-09-23T11:58:32Z
dc.date.issued2021-08-16
dc.description.abstractThe crystalline cyclic oligosaccharide γ-cyclodextrin (γCD) is a natural, non-toxic and biodegradable precursor that can be used to prepare innovative polymers. We cross-linked γCD with variable quantities of non-toxic polyethylene glycol diglycidyl ether (PEGDGE) in aqueous NaOH to form 3D structures with tunable physicochemical properties. Mixtures with a 5:1 PEGDGE:γCD molar ratio produced a cross-linked material that was soluble in water and organic solvents, underwent glass transition at –23 °C. The properties of this material were further modified by additional curing with PEGDGE or nitration reaction. Curing produced an insoluble polymeric material with excellent swelling abilities (200% in water) and decreased glass transition temperature to –37 °C. The nitrated cross-linked γCD was soluble in common organic solvents and underwent glass transition at +19 °C, achieving thermal stability below 190 °C. These novel γCD polymers are promising materials for applications in the pharmaceutical and food industries and environmental remediation.en_UK
dc.identifier.citationDossi E, Bolton M, Kister G, Afsar A. (2021) Cross-linking of γ-cyclodextrin using non-toxic polyethylene glycol spacer units. ChemistrySelect, Volume 6, Issue 3, August 2021, pp. 7727-7731en_UK
dc.identifier.issn2365-6549
dc.identifier.urihttps://doi.org/10.1002/slct.202101963
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/17096
dc.language.isoenen_UK
dc.publisherWileyen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectswellingen_UK
dc.subjectglass transitionen_UK
dc.subjectnon-toxic cross-linkeren_UK
dc.subjectwater solubleen_UK
dc.subjectcross-linked γ-cyclodextrinen_UK
dc.titleCross-linking of γ-cyclodextrin using non-toxic polyethylene glycol spacer unitsen_UK
dc.typeArticleen_UK

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