Microcalcification crystallography as a potential marker of DCIS recurrence

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dc.contributor.authorGosling, Sarah B.
dc.contributor.authorArnold, Emily
dc.contributor.authorDavies, Samantha K.
dc.date.accessioned2023-06-27T13:30:30Z
dc.date.available2023-06-27T13:30:30Z
dc.date.issued2023-06-08
dc.description.abstractDuctal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.en_UK
dc.identifier.citationGosling SB, Arnold, EL, Davies SK, et al. (2023) Microcalcification crystallography as a potential marker of DCIS recurrence. Scientific Reports, Volume 13, June 2023, Article number 9331en_UK
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-023-33547-8
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/19899
dc.language.isoenen_UK
dc.publisherSpringer Natureen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBiomarkersen_UK
dc.subjectBiomineralizationen_UK
dc.subjectBreast canceren_UK
dc.subjectCancer microenvironmenten_UK
dc.titleMicrocalcification crystallography as a potential marker of DCIS recurrenceen_UK
dc.typeArticleen_UK

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