Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight

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dc.contributor.authorHammer, Barbara
dc.contributor.authorKadalayil, Latha
dc.contributor.authorBoateng, Eistine
dc.contributor.authorBuschmann, Dominik
dc.contributor.authorRezwan, Faisal I.
dc.contributor.authorWolff, Martin
dc.contributor.authorReuter, Sebastian
dc.contributor.authorBartel, Sabine
dc.contributor.authorKnudsen, Toril Mørkve
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorHolloway, John W.
dc.contributor.authorKrauss-Etschmann, Susanne
dc.date.accessioned2021-06-08T13:23:33Z
dc.date.available2021-06-08T13:23:33Z
dc.date.issued2021-05-17
dc.description.abstractBackground Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested that preconceptional paternal smoking is associated with adolescent obesity in boys. We developed a murine adolescent smoking model before conception to investigate the paternal molecular causes of changes in offspring’s phenotype. Method Male and female C57BL/6J mice were exposed to increasing doses of mainstream cigarette smoke (CS) from onset of puberty for 6 weeks and mated with room air (RA) controls. Results Thirteen miRNAs were upregulated and 32 downregulated in the spermatozoa of CS-exposed fathers, while there were no significant differences in the count and morphological integrity of spermatozoa, as well as the proliferation of spermatogonia between CS- and RA-exposed fathers. Offspring from preconceptional CS-exposed mothers had lower body weights (p = 0.007). Moreover, data from offspring from CS-exposed fathers suggested a potential increase in body weight (p = 0.062). Conclusion We showed that preconceptional paternal CS exposure regulates spermatozoal miRNAs, and possibly influences the body weight of F1 progeny in early life. The regulated miRNAs may modulate transmittable epigenetic changes to offspring, thus influence the development of respiratory- and metabolic-related diseases such as obesity, a mechanism that warrants further studies for elaborate explanations.en_UK
dc.identifier.citationHammer B, Kadalayil L, Boateng E, et al., (2021) Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight. International Journal of Obesity, Volume 45, Number 7, July 2021, pp. 1623–1627en_UK
dc.identifier.issn0307-0565
dc.identifier.urihttps://doi.org/10.1038/s41366-021-00798-2
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16739
dc.language.isoenen_UK
dc.publisherNature Publishing Groupen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMetabolismen_UK
dc.subjectGeneticsen_UK
dc.titlePreconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weighten_UK
dc.typeArticleen_UK

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