A label free electrochemical nanobiosensor study

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dc.contributor.authorZhang, Juankun
dc.contributor.authorDong, Shanmu
dc.contributor.authorLu, Jinhui
dc.contributor.authorTurner, Anthony P. F.
dc.contributor.authorFan, Qingjie
dc.contributor.authorJia, Shiru
dc.contributor.authorYang, Hongjiang
dc.contributor.authorQiao, Changsheng
dc.contributor.authorZhou, Hao
dc.contributor.authorHe, Guowei
dc.date.accessioned2010-02-18T10:39:45Z
dc.date.available2010-02-18T10:39:45Z
dc.date.issued2009-01
dc.description.abstractNano-porous silicon (PS) is an attractive material for incorporation into biosensors, because it has a large surface area combined with the ability to generate both optical and electrical signals. In this paper, we describe a label-free nanobiosensor for bovine serum albumin (BSA). Nano-porous silicon produced in our laboratory was functionalized prior to immobilization of anti-BSA antibody on the surface. Reaction with BSA in phosphate buffered saline (PBS) buffer resulted in an impedance change which was inversely proportional to the concentration of the analyte. The system PBS buffer/antigen-antibody/PS constitutes an electrolyte-insulator-semiconductor (EIS) structure, thus furnishing an impedance EIS nanobiosensor. The linear range of the sensor was 0-0.27 mg mL-1 and the sensitivity was less than 10 µg mL-1.en_UK
dc.identifier.citationJuankun Zhang; Shanmu Dong; Jinhui Lu; Anthony P. F. Turner; Qingjie Fan; Shiru Jia; Hongjiang Yang; Changsheng Qiao; Hao Zhou; Guowei He, A label free electrochemical nanobiosensor study, Analytical Letters, Volume 42, Issue 17, January 2009 , pages 2905-2913en_UK
dc.identifier.issn0003-2719
dc.identifier.urihttp://dx.doi.org/10.1080/00032710903201941
dc.identifier.urihttp://hdl.handle.net/1826/4248
dc.language.isoenen_UK
dc.publisherTaylor & Francisen_UK
dc.subjectElectrolyte-insulator-semiconductoren_UK
dc.subjectimpedanceen_UK
dc.subjectnano-porous siliconen_UK
dc.subjectnanobiosensoren_UK
dc.titleA label free electrochemical nanobiosensor studyen_UK
dc.typeArticleen_UK

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