Age-related changes in femoral head trabecular microarchitecture

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dc.contributor.authorGreenwood, Charlene
dc.contributor.authorClement, John
dc.contributor.authorDicken, Anthony
dc.contributor.authorEvans, Paul
dc.contributor.authorLyburn, Iain Douglas
dc.contributor.authorMartin, Richard M.
dc.contributor.authorStone, Nick
dc.contributor.authorZioupos, Peter
dc.contributor.authorRogers, Keith
dc.date.accessioned2018-10-08T13:57:49Z
dc.date.available2018-10-08T13:57:49Z
dc.date.issued2017-10-11
dc.description.abstractOsteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density using dual energy X-ray absorption. However, many studies have shown that bone strength, and consequently the probability of fracture, is a combination of both bone mass and bone ‘quality’ (architecture and material chemistry). Although the microarchitecture of both non-fracture and osteoporotic bone has been previously investigated, many of the osteoporotic studies are constrained by factors such as limited sample number, use of ovariectomised animal models, and lack of male and female discrimination. This study reports significant differences in bone quality with respect to the microarchitecture between fractured and non-fractured human femur specimens. Micro-computed tomography was utilised to investigate the microarchitecture of femoral head trabecular bone from a relatively large cohort of non-fracture and fracture human donors. Various microarchitectural parameters have been determined for both groups, providing an understanding of the differences between fracture and non -fracture material. The microarchitecture of non-fracture and fracture bone tissue is shown to be significantly different for many parameters. Differences between sexes also exist, suggesting differences in remodelling between males and females in the fracture group. The results from this study will, in the future, be applied to develop a fracture model which encompasses bone density, architecture and material chemical properties for both female and male tissues.en_UK
dc.identifier.citationGreenwood C, Clement J, Dicken A. (2018) Age-related changes in femoral head trabecular microarchitecture. Aging and Disease, Volume 9, Issue 6, December 2018, pp. 976-987en_UK
dc.identifier.cris19958671
dc.identifier.issn2152-5250
dc.identifier.urihttps://doi.org/10.14336/AD.2018.0124
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/13513
dc.language.isoenen_UK
dc.publisherBuck Institute for Age Researchen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectmicro computed tomography (μ-CT)en_UK
dc.subjectosteoporosisen_UK
dc.subjectagingen_UK
dc.subjectmicroarchitectureen_UK
dc.subjecttrabecular boneen_UK
dc.subjectfemoral headen_UK
dc.titleAge-related changes in femoral head trabecular microarchitectureen_UK
dc.typeArticleen_UK

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