An improved model for the analysis of combined antimicrobials: a replacement for the Chou‐Talalay combination index method

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dc.contributor.authorAnastasiadi, Maria
dc.contributor.authorPolizzi, Karen
dc.contributor.authorLambert, Ronald J. W.
dc.date.accessioned2017-11-16T19:40:45Z
dc.date.available2017-11-16T19:40:45Z
dc.date.issued2017-10
dc.description.abstractAims To rationalise confusion in the literature concerning the analysis of combined antimicrobials, specifically to see if the combination index (CI) method of analysis was as rigorous as claimed. Methods & Results data from previous studies of the inhibition of Staphylococcus aureus by mixed antimicrobials were re-analysed using the CI method and a model which takes account of differences in the concentration exponents of individual antimicrobials. Conclusions The Chou-Talalay combination index method for the analysis of combined antimicrobials was found to be valid only in the specific cases where concentration exponents were equal. In these cases the CI method was found to be a function of the residuals of fitting the additive model to the observed data. Where concentration exponents were not equal the CI method was invalid, whereas the additive model took these differences into account. Significance and Impact of Study The CI method can be replaced wholly by the additive model described. The model allows simple regression to be used to analyse whole data sets and provides simple graphical output.en_UK
dc.identifier.citationMaria Anastasiadi, Karen Polizzi and Ronald J.W. Lambert. An improved model for the analysis of combined antimicrobials: a replacement for the Chou‐Talalay combination index method. Journal of Applied Microbiology, Volume 124, Issue 1, January 2018, pp97-107en_UK
dc.identifier.issn1364-5072
dc.identifier.urihttp://dx.doi.org/10.1111/jam.13623
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/12720
dc.language.isoenen_UK
dc.publisherWileyen_UK
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCombination Indexen_UK
dc.subjectsynergyen_UK
dc.subjectisobologramen_UK
dc.subjectmodellingen_UK
dc.subjectChou-Talalayen_UK
dc.titleAn improved model for the analysis of combined antimicrobials: a replacement for the Chou‐Talalay combination index methoden_UK
dc.typeArticleen_UK

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