Inactivation rates for airborne human coronavirus by low doses of 222nm far-UVC radiation

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dc.contributor.authorWelch, David
dc.contributor.authorBuonanno, Manuela
dc.contributor.authorBuchan, Andrew G.
dc.contributor.authorYang, Liang
dc.contributor.authorAtkinson, Kirk D.
dc.contributor.authorShuryak, Igor
dc.contributor.authorBrenner, David J.
dc.date.accessioned2022-04-05T12:39:17Z
dc.date.available2022-04-05T12:39:17Z
dc.date.issued2022-03-25
dc.description.abstractRecent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose–response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose–response relation, and the estimated susceptibility constant at low doses—the relevant parameter for realistic low dose rate exposures—was 12.4 ± 0.4 cm2/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens.en_UK
dc.description.sponsorshipEPSRC: EP/M022684/2 and Natural Sciences and Engineering Research Council of Canada (NSERC): IRCPJ 549979-19.en_UK
dc.identifier.citationWelch D, Buonanno M, Buchan AG, et al., (2022) Inactivation rates for airborne human coronavirus by low doses of 222nm far-UVC radiation, Viruses, Volume 14, Issue 4, March 2022, Article number 684en_UK
dc.identifier.issn1999-4915
dc.identifier.urihttps://doi.org/10.3390/v14040684
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/17739
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectultraviolet radiationen_UK
dc.subjectfar-UVCen_UK
dc.subjectcoronavirusen_UK
dc.subjectairborneen_UK
dc.subjectradiation transporten_UK
dc.subjectcomputational fluid dynamicsen_UK
dc.titleInactivation rates for airborne human coronavirus by low doses of 222nm far-UVC radiationen_UK
dc.typeArticleen_UK

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