Microfluidic production of multiple emulsions

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dc.contributor.authorVladisavljević, G. T.
dc.contributor.authorAl Nuumani, R.
dc.contributor.authorNabavi, Seyed Ali
dc.date.accessioned2017-03-31T10:29:55Z
dc.date.available2017-03-31T10:29:55Z
dc.date.issued2017-03-02
dc.description.abstractMicrofluidic devices are promising tools for the production of monodispersed tuneable complex emulsions. This review highlights the advantages of microfluidics for the fabrication of emulsions and presents an overview of the microfluidic emulsification methods including two-step and single-step methods for the fabrication of high-order multiple emulsions (double, triple, quadruple and quintuple) and emulsions with multiple and/or multi-distinct inner cores. The microfluidic methods for the formation of multiple emulsion drops with ultra-thin middle phase, multi-compartment jets, and Janus and ternary drops composed of two or three distinct surface regions are also presented. Different configurations of microfluidic drop makers are covered, such as co-flow, T-junctions and flow focusing (both planar and three-dimensional (3D)). Furthermore, surface modifications of microfluidic channels and different modes of droplet generation are summarized. Non-confined microfluidic geometries used for buoyancy-driven drop generation and membrane integrated microfluidics are also discussed. The review includes parallelization and drop splitting strategies for scaling up microfluidic emulsification. The productivity of a single drop maker is typically <1 mL/h; thus, more than 1000 drop makers are needed to achieve commercially relevant droplet throughputs of >1 L/h, which requires combining drop makers into twodimensional (2D) and 3D assemblies fed from a single set of inlet ports through a network of distribution and collection channelsen_UK
dc.identifier.citationVladisavljević, G.T.; Al Nuumani, R.; Nabavi, S.A. Microfluidic Production of Multiple Emulsions. Micromachines 2017, Volume 8, Issue 3, Article number 75.en_UK
dc.identifier.issn2072-666X
dc.identifier.urihttp://dx.doi.org/10.3390/mi8030075
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/11693
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International (CC BY 4.0) You are free to: Share — copy and redistribute the material in any medium or format, Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Information: No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
dc.subjectmicrofluidicsen_UK
dc.subjectmultiple emulsionen_UK
dc.subjectJanus dropen_UK
dc.subjectcore/shell dropsen_UK
dc.subjectflow focusingen_UK
dc.subjectmicrofibersen_UK
dc.subjectternary dropen_UK
dc.titleMicrofluidic production of multiple emulsionsen_UK
dc.typeArticleen_UK

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