Pre-adolescence DNA methylation is associated with BMI status change from pre-to post-adolescence

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dc.contributor.authorWang, Jiajing
dc.contributor.authorZhang, Hongmei
dc.contributor.authorRezwan, Faisal I.
dc.contributor.authorRelton, Caroline L.
dc.contributor.authorHasan Arshad, S.
dc.contributor.authorHolloway, John W.
dc.date.accessioned2021-04-15T14:11:23Z
dc.date.available2021-04-15T14:11:23Z
dc.date.issued2021-03-25
dc.description.abstractBackground: Previous studies have shown that DNA methylation (DNAm) is associated with body mass index (BMI). However, it is unknown whether DNAm at pre-adolescence is associated with BMI status transition from pre- to postadolescence. In the Isle of Wight (IoW) birth cohort, genome-wide DNA methylation in whole blood was measured using Illumina Infnium Human450 and EPIC BeadChip arrays in n=325 subjects, and pre- to post-adolescence BMI transition was classifed into four groups: (1) normal to normal, (2) normal to overweight or obese, (3) overweight or obese to normal, and (4) persistent overweight or obese. We used recursive random forest to screen genome-wide Cytosine-phosphate-Guanine (CpG) sites with DNAm potentially associated with BMI transition for each gender, and the association of BMI status transition with DNAm at an earlier age was assessed via logistic regressions. To evaluate gender specifcity, interactions between DNAm and gender were included in the model. Findings in the IoW cohort were further tested in an independent cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Results: In total, 174 candidate CpGs were selected including CpGs from screening and CpGs previously associated correctionally with BMI in children and adults. Of these 174 CpGs, pre-adolescent DNAm of 38 CpGs in the IoW cohort was associated with BMI status transition, including 30 CpGs showing gender-specifc associations. Thirteen CpGs showed consistent associations between the IoW cohort and the ALSPAC cohort (11 of which were gender-specifc). Conclusion: Pre-adolescence DNAm is associated with the change in BMI status from pre- to post-adolescence and such associations are likely to be gender-specifcen_UK
dc.identifier.citationWang J, Zhang H, Rezwan FI, et al., (2021) Pre-adolescence DNA methylation is associated with BMI status change from pre-to post-adolescence. Clinical Epigenetics, Volume 13, March 2021, Article number 64en_UK
dc.identifier.issn1868-7075
dc.identifier.urihttps://doi.org/10.1186/s13148-021-01042-4
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16580
dc.language.isoenen_UK
dc.publisherBMC (part of Springer Nature)en_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectObesityen_UK
dc.subjectBMI status transitionen_UK
dc.subjectBody mass index (BMI)en_UK
dc.subjectLongitudinalen_UK
dc.subjectDNA methylationen_UK
dc.subjectAdolescenceen_UK
dc.titlePre-adolescence DNA methylation is associated with BMI status change from pre-to post-adolescenceen_UK
dc.typeArticleen_UK

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