The cortical focus in childhood absence epilepsy; evidence from nonlinear analysis of scalp EEG recordings

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dc.contributor.authorSarrigiannis, Ptolemaios G.
dc.contributor.authorZhao, Yifan
dc.contributor.authorHe, Fei
dc.contributor.authorBillings, Stephen A.
dc.contributor.authorBaster, Kathleen
dc.contributor.authorRittey, Chris
dc.contributor.authorYianni, John
dc.contributor.authorZis, Panagiotis
dc.contributor.authorWei, Hua-Liang
dc.contributor.authorHadjivassiliou, Marios
dc.contributor.authorGrünewald, Richard
dc.date.accessioned2018-01-15T10:20:00Z
dc.date.available2018-01-15T10:20:00Z
dc.date.issued2018-01-08
dc.description.abstractObjective To determine the origin and dynamic characteristics of the generalised hyper-synchronous spike and wave (SW) discharges in childhood absence epilepsy (CAE). Methods We applied nonlinear methods, the error reduction ratio (ERR) causality test and cross-frequency analysis, with a nonlinear autoregressive exogenous (NARX) model, to electroencephalograms (EEGs) from CAE, selected with stringent electro-clinical criteria (17 cases, 42 absences). We analysed the pre-ictal and ictal strength of association between homologous and heterologous EEG derivations and estimated the direction of synchronisation and corresponding time lags. Results A frontal/fronto-central onset of the absences is detected in 13 of the 17 cases with the highest ictal strength of association between homologous frontal followed by centro-temporal and fronto-central areas. Delays consistently in excess of 4 ms occur at the very onset between these regions, swiftly followed by the emergence of “isochronous” (0-2ms) synchronisation but dynamic time lag changes occur during SW discharges. Conclusions In absences an initial cortico-cortical spread leads to dynamic lag changes to include periods of isochronous interhemispheric synchronisation, which we hypothesize is mediated by the thalamus. Significance Absences from CAE show ictal epileptic network dynamics remarkably similar to those observed in WAG/Rij rats which guided the formulation of the cortical focus theory.en_UK
dc.identifier.citationPtolemaios G. Sarrigiannis, Yifan Zhao, Fei He, et al., The cortical focus in childhood absence epilepsy; evidence from nonlinear analysis of scalp EEG recordings, Clinical Neurophysiology, Volume 129, Issue 3, March 2018, Pages 602-617en_UK
dc.identifier.issn1388-2457
dc.identifier.urihttp://dx.doi.org/10.1016/j.clinph.2017.11.029
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/12890
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAbsenceen_UK
dc.subjectZero-Lagen_UK
dc.subjectNonlinearen_UK
dc.subjectCortical focus theoryen_UK
dc.subjectThalamusen_UK
dc.subjectERR causality testen_UK
dc.titleThe cortical focus in childhood absence epilepsy; evidence from nonlinear analysis of scalp EEG recordingsen_UK
dc.typeArticleen_UK

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