Differential susceptibility of catheter biomaterials to biofilm-associated infections and their remedy by drug-encapsulated Eudragit RL100 nanoparticles

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dc.contributor.authorPandey, Vivek Kumar
dc.contributor.authorSrivastava, Kumar Rohit
dc.contributor.authorAjmal, Gufran
dc.contributor.authorThakur, Vijay Kumar
dc.contributor.authorGupta, Vijai Kumar
dc.contributor.authorUpadhyay, Siddh Nath
dc.contributor.authorMishra, Pradeep Kumar
dc.date.accessioned2020-01-14T18:52:50Z
dc.date.available2020-01-14T18:52:50Z
dc.date.issued2019-10-15
dc.description.abstractBiofilms are the cause of major bacteriological infections in patients. The complex architecture of Escherichia coli (E. coli) biofilm attached to the surface of catheters has been studied and found to depend on the biomaterial’s surface properties. The SEM micrographs and water contact angle analysis have revealed that the nature of the surface a ects the growth and extent of E. coli biofilm formation. In vitro studies have revealed that the Gram-negative E. coli adherence to implanted biomaterials takes place in accordance with hydrophobicity, i.e., latex > silicone > polyurethane > stainless steel. Permanent removal of E. coli biofilm requires 50 to 200 times more gentamicin sulfate (G-S) than the minimum inhibitory concentration (MIC) to remove 90% of E. coli biofilm (MBIC90). Here, in vitro eradication of biofilm-associated infection on biomaterials has been done by Eudragit RL100 encapsulated gentamicin sulfate (E-G-S) nanoparticle of range 140 nm. It is 10–20 times more e ective against E. coli biofilm-associated infections eradication than normal unentrapped G-S. Thus, Eudragit RL100 mediated drug delivery system provides a promising way to reduce the cost of treatment with a higher drug therapeutic index.en_UK
dc.identifier.citationPandey VK, Srivastava KR, Ajmal G, et al., (2019) Differential susceptibility of catheter biomaterials to biofilm-associated infections and their remedy by drug-encapsulated Eudragit RL100 nanoparticles. International Journal of Molecular Sciences, Volume 20, Issue 20, October 2019. Article number 5110en_UK
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms20205110
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/14921
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectE. colien_UK
dc.subjectbiofilmen_UK
dc.subjectnanoparticle-mediated drug deliveryen_UK
dc.subjectantibioticsen_UK
dc.subjectcathetersen_UK
dc.subjectbiomaterialsen_UK
dc.titleDifferential susceptibility of catheter biomaterials to biofilm-associated infections and their remedy by drug-encapsulated Eudragit RL100 nanoparticlesen_UK
dc.typeArticleen_UK

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