Molecularly imprinted nanoparticles based sensor for cocaine detection

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dc.contributor.authorD’Aurelio, Roberta
dc.contributor.authorChianella, Iva
dc.contributor.authorGoode, Jack A.
dc.contributor.authorTothill, Ibtisam E.
dc.date.accessioned2020-03-25T16:41:54Z
dc.date.available2020-03-25T16:41:54Z
dc.date.issued2020-03-04
dc.description.abstractThe development of a sensor based on molecularly imprinted polymer nanoparticles (nanoMIPs) and electrochemical impedance spectroscopy (EIS) for the detection of trace levels of cocaine is described in this paper. NanoMIPs for cocaine detection, synthesized using a solid phase, were applied as the sensing element. The nanoMIPs were first characterized by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering and found to be ~148.35 ± 24.69 nm in size, using TEM. The nanoMIPs were then covalently attached to gold screen-printed electrodes and a cocaine direct binding assay was developed and optimized, using EIS as the sensing principle. EIS was recorded at a potential of 0.12 V over the frequency range from 0.1 Hz to 50 kHz, with a modulation voltage of 10 mV. The nanoMIPs sensor was able to detect cocaine in a linear range between 100 pg mL−1 and 50 ng mL−1 (R2 = 0.984; p-value = 0.00001) and with a limit of detection of 0.24 ng mL−1 (0.70 nM). The sensor showed no cross-reactivity toward morphine and a negligible response toward levamisole after optimizing the sensor surface blocking and assay conditions. The developed sensor has the potential to offer a highly sensitive, portable and cost-effective method for cocaine detection.en_UK
dc.identifier.citationD’Aurelio R, Chianella I, Goode JA, et al., (2020) Molecularly imprinted nanoparticles based sensor for cocaine detection. Biosensors, Volume 10, Issue 3, March 2020, Article number 22en_UK
dc.identifier.issn2079-6374
dc.identifier.urihttps://doi.org/10.3390/bios10030022
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/15326
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCocaineen_UK
dc.subjectDrugs of abuseen_UK
dc.subjectElectrochemical impedance spectroscopyen_UK
dc.subjectmolecularly imprinted polymer nanoparticlesen_UK
dc.subjectEIS sensoren_UK
dc.titleMolecularly imprinted nanoparticles based sensor for cocaine detectionen_UK
dc.typeArticleen_UK

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