Oxytetracycline recovery from aqueous media using computationally designed molecularly imprinted polymers

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dc.contributor.authorRodríguez Dorado, R.
dc.contributor.authorCarro, A. M.
dc.contributor.authorChianella, Iva
dc.contributor.authorKarim, K.
dc.contributor.authorConchiero, A.
dc.contributor.authorlornzo, R. A.
dc.contributor.authorPiletsky, Sergey A.
dc.contributor.authorAlvarez-Lorenzo, C.
dc.date.accessioned2016-11-03T11:35:10Z
dc.date.available2016-11-03T11:35:10Z
dc.date.issued2016-08-03
dc.description.abstractPolymers for recovery/removal of the antimicrobial agent oxytetracycline (OTC) from aqueous media were developed with use of computational design and molecular imprinting. 2-Hydroxyethyl methacrylate, 2-acrylamide-2-methylpropane sulfonic acid (AMPS), and mixtures of the two were chosen according to their predicted affinity for OTC and evaluated as functional monomers in molecularly imprinted polymers and nonimprinted polymers. Two levels of AMPS were tested. After bulk polymerization, the polymers were crushed into particles (200–1000 μm). Pressurized liquid extraction was implemented for template removal with a low amount of methanol (less than 20 mL in each extraction) and a few extractions (12–18 for each polymer) in a short period (20 min per extraction). Particle size distribution, microporous structure, and capacity to rebind OTC from aqueous media were evaluated. Adsorption isotherms obtained from OTC solutions (30–110 mg L-1) revealed that the polymers prepared with AMPS had the highest affinity for OTC. The uptake capacity depended on the ionic strength as follows: purified water > saline solution (0.9 % NaCl) > seawater (3.5 % NaCl). Polymer particles containing AMPS as a functional monomer showed a remarkable ability to clean water contaminated with OTC. The usefulness of the stationary phase developed for molecularly imprinted solid-phase extraction was also demonstrated.en_UK
dc.identifier.citationRodríguez-Dorado R, Carro AM, Chianella I, et al., Oxytetracycline recovery from aqueous media using computationally designed molecularly imprinted polymers, Analytical and Bioanalytical Chemistry, Vol. 408, Issue 24, September 2016, pp. 6845-6856en_UK
dc.identifier.issn1618-2642
dc.identifier.urihttp://dx.doi.org/10.1007/s00216-016-9811-6
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/10933
dc.language.isoenen_UK
dc.publisherSpringer Verlag (Germany)en_UK
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectComputational designen_UK
dc.subjectMolecularly imprinted polymeren_UK
dc.subjectOxytetracyclineen_UK
dc.subjectRebinding isothernen_UK
dc.subjectSolid-phase extractionen_UK
dc.subjectGroundwater remediationen_UK
dc.titleOxytetracycline recovery from aqueous media using computationally designed molecularly imprinted polymersen_UK
dc.typeArticleen_UK

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