Toward in-vivo cancer detection: X-ray scattering on thick phantom samples

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dc.contributor.authorKubytskyi, Viacheslav
dc.contributor.authorKhonkhodzhaev, Masroor
dc.contributor.authorTanaka, Aika
dc.contributor.authorNguyen, Audrey
dc.contributor.authorLazarev, Alexander
dc.contributor.authorAram, Byron
dc.contributor.authorRogers, Keith
dc.contributor.authorMourokh, Lev
dc.contributor.authorLazarev, Pavel
dc.date.accessioned2025-04-17T13:45:25Z
dc.date.available2025-04-17T13:45:25Z
dc.date.freetoread2025-04-17
dc.date.issued2025-04-08
dc.date.pubOnline2025-04-08
dc.descriptionThis article belongs to the Section Photochemistry
dc.description.abstractAs the number of new breast cancer cases grows around the world, there is an unmet need for fast, accurate, and low-cost methods of early cancer detection. It was previously shown that X-ray scattering on lipid molecules can provide the necessary structural biomarker. However, these measurements were performed on small ex vivo samples, and to ensure the progress to in vivo diagnostics, the approach should be extended to larger tissues. We use the phantom fat samples to establish such a procedure. In the obtained X-ray scattering patterns, we observe the characteristic features for the inter-fatty-acid molecular distance. The large size of the samples led to the peak broadening; however, the features remain visible up to 10 cm in thickness. The experimental data are in excellent agreement with the Monte Carlo simulations based on the form factors obtained from the small samples. Our results usher the way for the in vivo monitoring of the structural biomarkers of breast cancer.
dc.description.journalNameMolecules
dc.identifier.citationKubytskyi V, Khonkhodzhaev M, Tanaka A, et al., (2025) Toward in-vivo cancer detection: X-ray scattering on thick phantom samples. Molecules, Volume 30, Issue 8, April 2025, Article number 1655
dc.identifier.eissn1420-3049
dc.identifier.elementsID564699
dc.identifier.issueNo8
dc.identifier.paperNo1655
dc.identifier.urihttps://doi.org/10.3390/molecules30081655
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23773
dc.identifier.volumeNo30
dc.language.isoen
dc.publisherMDPI
dc.publisher.urihttps://www.mdpi.com/1420-3049/30/8/1655
dc.relation.isreferencedbyhttps://doi.org/10.5281/zenodo.14775480
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject32 Biomedical and Clinical Sciences
dc.subject34 Chemical Sciences
dc.subject3211 Oncology and Carcinogenesis
dc.subjectBioengineering
dc.subjectWomen's Health
dc.subjectBreast Cancer
dc.subjectCancer
dc.subjectPrevention
dc.subject4.1 Discovery and preclinical testing of markers and technologies
dc.subjectCancer
dc.subjectcancer detection
dc.subjectX-ray scattering
dc.subjectMonte Carlo simulations
dc.subjectstructural biomarkers
dc.subjectlipid molecules
dc.titleToward in-vivo cancer detection: X-ray scattering on thick phantom samples
dc.typeArticle
dcterms.dateAccepted2025-04-04

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