Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle

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dc.contributor.authorLarrañaga-Altuna, Mikel
dc.contributor.authorZabala, Alaitz
dc.contributor.authorLlavori, Iñigo
dc.contributor.authorPearce, Oliver
dc.contributor.authorNguyen, Dinh T.
dc.contributor.authorCaro, Jaume
dc.contributor.authorMescheder, Holger
dc.contributor.authorEndrino, José L.
dc.contributor.authorGoel, Gaurav
dc.contributor.authorAyre, Wayne Nishio
dc.contributor.authorSeenivasagam, Rajkumar Kottayasamy
dc.contributor.authorTripathy, Debendra Kumar
dc.contributor.authorArmstrong, Joe
dc.contributor.authorGoel, Saurav
dc.date.accessioned2021-04-12T15:37:12Z
dc.date.available2021-04-12T15:37:12Z
dc.date.issued2021-04-06
dc.description.abstractProgress made by materials scientists in recent years has greatly helped the field of ultra-precision manufacturing. Ranging from healthcare to electronics components, phenomena such as twinning, dislocation nucleation and high-pressure phase transformation have helped to exploit plasticity across a wide range of metallic and semiconductor materials. One current problem at the forefront of the healthcare sector that can benefit from these advances is that of bacterial infections in implanted prosthetic devices. The treatment of implant infections is often complicated by the growth of bacterial biofilms on implant surfaces, which form a barrier that effectively protects the infecting organisms from host immune defences and exogenous antibiotics. Further surgery is usually required to disrupt the biofilm, or to remove the implant altogether to permit antibiotics to clear the infection, incurring considerable cost and healthcare burdens. In this review, we focus on elucidating aspects of bactericidal surfaces inspired by the biological world to inform the design of implant surface treatments that will suppress bacterial colonization. Alongside manufacturing and materials related challenges, the review identifies the most promising natural bactericidal surfaces and provides representative models of their structure, highlighting the importance of the critical slope presented by these surfaces. The scalabl production of these complex hierarchical structures on freeform metallic implant surfaces has remained a scientific challenge to date and as identified by this review, is one of the many 21st Century puzzles to be addressed by the field of applied physics.en_UK
dc.identifier.citationLarranaga-Altuna M, Zabala A, Llavori I, et al., (2021) Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews, Volume 8, Issue 2, June 2021, Article number 021303en_UK
dc.identifier.issn1931-9401
dc.identifier.urihttps://doi.org/10.1063/5.0028844
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/16553
dc.language.isoenen_UK
dc.publisherAmerican Institute of Physics (AIP)en_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectcontact angleen_UK
dc.subjectBactericidal surfacesen_UK
dc.subjectNature-inspired surfacesen_UK
dc.subjectImplantsen_UK
dc.titleBactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzleen_UK
dc.typeArticleen_UK

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