Critical review of nanopillar-based mechanobactericidal systems

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dc.contributor.authorHawi, Sara
dc.contributor.authorGoel, Saurav
dc.contributor.authorKumar, Vinod
dc.contributor.authorPearce, Oliver
dc.contributor.authorNishio Ayre, Wayne
dc.contributor.authorIvanova, Elena P.
dc.date.accessioned2022-01-19T11:19:37Z
dc.date.available2022-01-19T11:19:37Z
dc.date.issued2022-01-05
dc.description.abstractThe rise of multidrug-resistant bacteria is the biggest threat to human health globally, as described by the World Health Organization. Mechanobactericidal surfaces provide a sustainable approach to addressing this concern by eradicating pathogens, especially bacteria, “right-at-the-point” of contacting the surface. However, the lack of a “design to manufacture” approach due to our limited understanding of the mechanobactericidal mechanism has impeded engineering optimization to develop scalable exploitation routes in various healthcare applications. It can be argued that the reason, most particularly, is the limitations and uncertainties associated with the current instrumentation and simulation capabilities, which has led to several streams of test protocols. This review highlights the current understanding on the mechanobactericidal mechanisms in light of the contributing factors and various techniques that are used to postulate these mechanisms. The review offers a critique on the variations observed on how nanostructured surfaces found in the literature have been evaluated such that the test protocols and outcomes are incomparable. The review also shows a strong need for developing more accurate models of a bacterium because the currently reported experimental data are insufficient to develop bacterial material models (constitutive equations). The review also alludes to the scarcity of direct experimental evidence of the mechanobactericidal mechanism, suggesting a strong need for further in situ monitoring as a future research direction.en_UK
dc.identifier.citationHawi S, Goel S, Kumar V, et al., (2022) Critical review of nanopillar-based mechanobactericidal systems. ACS Applied Nano Materials, Volume 5, Issue 1, January 2022, pp. 1-17en_UK
dc.identifier.issn2574-0970
dc.identifier.urihttps://doi.org/10.1021/acsanm.1c03045
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/17436
dc.language.isoenen_UK
dc.publisherAmerican Chemical Societyen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectmechanobactericidalen_UK
dc.subjectnanostructured surfacesen_UK
dc.subjectbiomimicryen_UK
dc.subjectnature inspirationen_UK
dc.subjectengineering biologyen_UK
dc.titleCritical review of nanopillar-based mechanobactericidal systemsen_UK
dc.typeArticleen_UK

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