Paper-based microfluidics for rapid diagnostics and drug delivery

Simple item page
dc.contributor.authorMao, Kang
dc.contributor.authorMin, Xiaocui
dc.contributor.authorZhang, Hua
dc.contributor.authorCao, Haorui
dc.contributor.authorGuo, Yongkun
dc.contributor.authorYang, Zhugen
dc.date.accessioned2020-03-13T14:53:58Z
dc.date.available2020-03-13T14:53:58Z
dc.date.issued2020-03-10
dc.description.abstractPaper is a common material that is promising for constructing microfluidic chips (lab-on-a-paper) for diagnostics and drug delivery for biomedical applications. In the past decade, extensive research on paper-based microfluidics has accumulated a large number of scientific publications in the fields of biomedical diagnosis, food safety, environmental health, drug screening and delivery. This review focuses on the recent progress on paper-based microfluidic technology with an emphasis on the design, optimization and application of the technology platform, in particular for medical diagnostics and drug delivery. Novel advances have concentrated on engineering paper devices for point-of-care (POC) diagnostics, which could be integrated with nucleic acid-based tests and isothermal amplification experiments, enabling rapid sample-to-answer assays for field testing. Among the isothermal amplification experiments, loop-mediated isothermal amplification (LAMP), an extremely sensitive nucleic acid test, specifically identifies ultralow concentrations of DNA/RNA from practical samples for diagnosing diseases. We thus mainly focus on the paper device-based LAMP assay for the rapid infectious disease diagnosis, foodborne pathogen analysis, veterinary diagnosis, plant diagnosis, and environmental public health evaluation. We also outlined progress on paper microfluidic devices for drug delivery. The paper concludes with a discussion on the challenges of this technology and our insights into how to advance science and technology towards the development of fully functional paper devices in diagnostics and drug delivery.en_UK
dc.identifier.citationMao K, Min X, Zhang H, et al., (2020) Paper-based microfluidics for rapid diagnostics and drug delivery. Journal of Controlled Release, Volume 322, June 2020, pp. 187-199en_UK
dc.identifier.issn0168-3659
dc.identifier.urihttps://doi.org/10.1016/j.jconrel.2020.03.010
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/15281
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPaper-based microfluidicsen_UK
dc.subjectdrug deliveryen_UK
dc.subjectdiagnosticen_UK
dc.subjectLAMPen_UK
dc.titlePaper-based microfluidics for rapid diagnostics and drug deliveryen_UK
dc.typeArticleen_UK

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Paper-based_microfluidics_for_rapid_diagnostics-2020.pdf
Size:
1.12 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Staff publications (SWEE)