Review of paper-based microfluidic analytical devices for in-field testing of pathogens

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dc.contributor.authorLi, Wenliang
dc.contributor.authorMa, Xuanye
dc.contributor.authorYong, Yang-Chun
dc.contributor.authorLiu, Guozhen
dc.contributor.authorYang, Zhugen
dc.date.accessioned2023-09-19T13:14:45Z
dc.date.available2023-09-19T13:14:45Z
dc.date.issued2023-09-12
dc.description.abstractPathogens cause various infectious diseases and high morbidity and mortality which is a global public health threat. The highly sensitive and specific detection is of significant importance for the effective treatment and intervention to minimise the impact. However, conventional detection methods including culture and molecular method gravely depend on expensive equipment and well-trained skilled personnel, limiting in the laboratory. It remains challenging to adapt in resource-limiting areas, e.g., low and middle-income countries (LMICs). To this end, low-cost, rapid, and sensitive detection tools with the capability of field testing e.g., a portable device for identification and quantification of pathogens, has attracted increasing attentions. Recently, paper-based microfluidic analytical devices (μPADs) have shown a promising tool for rapid and on-site diagnosis, providing a cost-effective and sensitive analytical approach for pathogens detection. The fast turn-round data collection may also contribute to better understanding of the risks and insights on mitigation method. In this paper, critical developments of μPADs for in-field detection of pathogens both for clinical diagnostics and environmental surveillance are reviewed. The future development, and challenges of μPADs for rapid and onsite detection of pathogens are discussed, including using the cross-disciplinary development with, emerging techniques such as deep learning and Internet of Things (IoT).en_UK
dc.identifier.citationLi W, Ma X, Yong YC, et al., (2023) Review of paper-based microfluidic analytical devices for in-field testing of pathogens. Analytica Chimica Acta, Volume 1278, October 2023, Article number 341614en_UK
dc.identifier.issn0003-2670
dc.identifier.urihttps://doi.org/10.1016/j.aca.2023.341614
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/20249
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPaper analytical detectionen_UK
dc.subjectPathogen detectionen_UK
dc.subjectField testingen_UK
dc.subjectEnvironmental monitoringen_UK
dc.titleReview of paper-based microfluidic analytical devices for in-field testing of pathogensen_UK
dc.typeArticleen_UK

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