Towards the development of multisensor for drugs of abuse based on molecular imprinted polymers.

dc.contributor.authorPiletska, Elena V.-
dc.contributor.authorRomero-Guerra, M.-
dc.contributor.authorChianella, Iva-
dc.contributor.authorKarim, K.-
dc.contributor.authorTurner, Anthony P. F.-
dc.contributor.authorPiletsky, Sergey A.-
dc.date.accessioned2012-02-03T23:07:37Z
dc.date.available2012-02-03T23:07:37Z
dc.date.issued2005-06-22T00:00:00Z-
dc.description.abstractThe synthetic receptors for cocaine, deoxyephedrine, methadone and morphine were computationally designed and produced using molecular imprinting. The structure and energy of the molecular complexes were analysed by computational techniques. The possible structures of the binding sites in the synthetic receptors have been compared with those of corresponding natural receptors. The composition of imprinted polymers was optimised to allow adequate performance under the same experimental conditions. All selected molecular imprinting polymers (MIPs) demonstrated stronger affinity in comparison with corresponding blank polymers resulting in imprinted factors (I) equal to 1.2 (cocaine), 2.5 (deoxyephedrine), 3.5 (methadone) and 3 (morphine) which suggested that the specific binding site for each molecule was successfully created. The polymers studied possessed good selectivity and affinity towards their templates and could be recommended for the integration with sensor devices. From a practical point of view, especially for multisensor requirements, the synthetic receptors based on imprinted polymers could be superior to natural receptors due to their stability, robustness and compatibility with automation processes required for sensor fabrication.en_UK
dc.identifier.citationElena V. Piletska, Maria Romero-Guerra, Iva Chianella, Kal Karim, Anthony P.F. Turner, Sergey A. Piletsky, Towards the development of multisensor for drugs of abuse based on molecular imprinted polymers, Analytica Chimica Acta. Vol. 542, Issue 1, Papers presented at the 3rd International Workshop on Molecularly Imprinted Polymers, 22 June 2005, p. 111-117.-
dc.identifier.issn0003-2670-
dc.identifier.urihttp://dx.doi.org/10.1016/j.aca.2005.03.067-
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/2769
dc.language.isoen_UK-
dc.publisherElsevier Science B.V., Amsterdam.en_UK
dc.subjectCocaineen_UK
dc.subjectDeoxyephedrineen_UK
dc.subjectMethadoneen_UK
dc.subjectMorphineen_UK
dc.subjectMolecular imprintingen_UK
dc.subjectMolecular modellingen_UK
dc.subjectHPLCen_UK
dc.subjectSensoren_UK
dc.titleTowards the development of multisensor for drugs of abuse based on molecular imprinted polymers.en_UK
dc.typeArticle-

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