Synergistic air pollution exposure elevates depression risk: a cohort study

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dc.contributor.authorHao, Yuqing
dc.contributor.authorXu, Longzhu
dc.contributor.authorPeng, Meiyu
dc.contributor.authorYang, Zhugen
dc.contributor.authorWang, Weiqi
dc.contributor.authorMeng, Fanyu
dc.date.accessioned2024-12-17T10:40:23Z
dc.date.available2024-12-17T10:40:23Z
dc.date.freetoread2024-12-17
dc.date.issued2025-01
dc.date.pubOnline2024-11-28
dc.description.abstractDepression is a leading mental health disorder worldwide, contributing substantially to the global disease burden. While emerging evidence suggests links between specific air pollutants and depression, the potential interactions among multiple pollutants remain underexplored. Here we show the influence of six common air pollutants on depressive symptoms among middle-aged and older Chinese adults. In single-pollutant models, a 10 μg m−3 increase in SO2, CO, PM10, and PM2.5 is associated with increased risks of depressive symptoms, with odds ratios (95% confidence intervals) of 1.276 (1.238–1.315), 1.007 (1.006–1.008), 1.066 (1.055–1.078), and 1.130 (1.108–1.153), respectively. In two-pollutant models, SO2 remains significantly associated with depressive symptoms after adjusting for other pollutants. Multi-pollutant models uncover synergistic effects, with SO2, CO, NO2, PM10, and PM2.5 exhibiting significant interactions, identifying SO2 as the primary driver of these associations. Mediation analyses further indicate that cognitive and physical impairments partially mediate the relationship between air pollution and depressive symptoms. These findings underscore the critical mental health impacts of air pollution and highlight the need for integrated air quality management strategies. Targeted mitigation of specific pollutants, particularly SO2, is expected to significantly enhance public mental health outcomes.
dc.description.journalNameEnvironmental Science and Ecotechnology
dc.description.sponsorshipThe authors gratefully acknowledge funding from Project LH2021E097, supported by the Natural Science Foundation of Heilongjiang Province, Project QMPT-2007, supported by Harbin Medical University, with the support of the China Scholarship Council.
dc.identifier.citationHao Y, Xu L, Peng M, et al., (2025) Synergistic air pollution exposure elevates depression risk: a cohort study. Environmental Science and Ecotechnology, Volume 23, January 2025, Article number 100515
dc.identifier.eissn2666-4984
dc.identifier.elementsID559377
dc.identifier.issn2666-4984
dc.identifier.paperNo100515
dc.identifier.urihttps://doi.org/10.1016/j.ese.2024.100515
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23290
dc.identifier.volumeNo23
dc.languageEnglish
dc.language.isoen
dc.publisherElsevier
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S2666498424001297?via%3Dihub
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject41 Environmental Sciences
dc.subject4105 Pollution and Contamination
dc.subjectClinical Research
dc.subjectBehavioral and Social Science
dc.subjectClimate-Related Exposures and Conditions
dc.subjectMental Illness
dc.subjectMental Health
dc.subjectSocial Determinants of Health
dc.subjectBrain Disorders
dc.subjectDepression
dc.subject2.2 Factors relating to the physical environment
dc.subjectMental health
dc.subject3 Good Health and Well Being
dc.subject4011 Environmental engineering
dc.subject4103 Environmental biotechnology
dc.subject4104 Environmental management
dc.subjectAir pollution
dc.subjectLong-term exposure
dc.subjectDepressive symptoms
dc.subjectJoint effect
dc.subjectMediation analysis
dc.titleSynergistic air pollution exposure elevates depression risk: a cohort study
dc.typeArticle
dc.type.subtypeJournal Article
dcterms.dateAccepted2024-11-20

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