A critical role for host-derived cystathionine-β-synthase, in Staphylococcus aureus-induced udder infection

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dc.contributor.authorFu, Shaodong
dc.contributor.authorYang, Bo
dc.contributor.authorGao, Yabin
dc.contributor.authorQiu, Yawei
dc.contributor.authorSun, Naiyan
dc.contributor.authorLi, Zhi
dc.contributor.authorFeng, Shiyuan
dc.contributor.authorXu, Yuanyuan
dc.contributor.authorZhang, Jinqiu
dc.contributor.authorLuo, Zhenhua
dc.contributor.authorHan, Xiangan
dc.contributor.authorMiao, Jinfeng
dc.date.accessioned2023-11-16T16:08:55Z
dc.date.available2023-11-16T16:08:55Z
dc.date.issued2023-11-10
dc.description.abstractCystathionine-β-synthase (CBS) catalyzes the first step of the transsulfuration pathway. The role of host-derived CBS in Staphylococcus aureus (S. aureus)-induced udder infection remains elusive. Herein, we report that S. aureus infection enhances the expression of CBS in mammary epithelial cells in vitro and in vivo. A negative correlation is present between the expression of CBS and inflammation after employing a pharmacological inhibitor/agonist of CBS. In addition, CBS achieves a fine balance between eliciting sufficient protective innate immunity and preventing excessive damage to cells and tissues preserving the integrity of the blood-milk barrier (BMB). CBS/H2S reduces bacterial load by promoting the generation of antibacterial substances (ROS, RNS) and inhibiting apoptosis, as opposed to relying solely on intense inflammatory reactions. Conversely, H2S donor alleviate inflammation via S-sulfhydrating HuR. Finally, CBS/H2S promotes the expression of Abcb1b, which in turn strengthens the integrity of the BMB. The study described herein demonstrates the importance of CBS in regulating the mammary immune response to S. aureus. Increased CBS in udder tissue modulates excessive inflammation, which suggests a novel target for drug development in the battle against S. aureus and other infections.en_UK
dc.identifier.citationFu S, Yang B, Gao Y, et al., (2024) A critical role for host-derived cystathionine-β-synthase, in Staphylococcus aureus-induced udder infection. Free Radical Biology and Medicine, Volume 210, January 2024, pp. 13-24en_UK
dc.identifier.issn0891-5849
dc.identifier.urihttps://doi.org/10.1016/j.freeradbiomed.2023.11.001
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/20552
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectStaphylococcus aureusen_UK
dc.subjectCystathionine-β-synthaseen_UK
dc.subjectUdder infectionen_UK
dc.subjectBlood–milk barrieren_UK
dc.titleA critical role for host-derived cystathionine-β-synthase, in Staphylococcus aureus-induced udder infectionen_UK
dc.typeArticleen_UK

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