Breath analysis in disease diagnosis: methodological considerations and applications

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dc.contributor.authorLourenco, Celia
dc.contributor.authorTurner, Claire
dc.date.accessioned2018-01-11T16:35:46Z
dc.date.available2018-01-11T16:35:46Z
dc.date.issued2014-06-20
dc.description.abstractBreath analysis is a promising field with great potential for non-invasive diagnosis of a number of disease states. Analysis of the concentrations of volatile organic compounds (VOCs) in breath with an acceptable accuracy are assessed by means of using analytical techniques with high sensitivity, accuracy, precision, low response time, and low detection limit, which are desirable characteristics for the detection of VOCs in human breath. “Breath fingerprinting”, indicative of a specific clinical status, relies on the use of multivariate statistics methods with powerful in-built algorithms. The need for standardisation of sample collection and analysis is the main issue concerning breath analysis, blocking the introduction of breath tests into clinical practice. This review describes recent scientific developments in basic research and clinical applications, namely issues concerning sampling and biochemistry, highlighting the diagnostic potential of breath analysis for disease diagnosis. Several considerations that need to be taken into account in breath analysis are documented here, including the growing need for metabolomics to deal with breath profiles.en_UK
dc.identifier.citationCélia Lourenço and Claire Turner. Breath analysis in disease diagnosis: methodological considerations and applications. Metabolites 2014, Vol. 4, Iss. 2, pp465-498en_UK
dc.identifier.issn2218-1989
dc.identifier.urihttp://dx.doi.org/10.3390/metabo4020465
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/12884
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectvolatile organic compounds (VOCs)en_UK
dc.subjecttrace gas analysisen_UK
dc.subjectvolatile biomarkersen_UK
dc.subjectmetabolomicsen_UK
dc.titleBreath analysis in disease diagnosis: methodological considerations and applicationsen_UK
dc.typeArticleen_UK

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