DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Simple item page
dc.contributor.authorVehmeijer, Florianne O. L.
dc.contributor.authorKüpers, Leanne K.
dc.contributor.authorSharp, Gemma C.
dc.contributor.authorSalas, Lucas A.
dc.contributor.authorLent, Samantha
dc.contributor.authorJima, Dereje D.
dc.contributor.authorTindula, Gwen
dc.contributor.authorReese, Sarah
dc.contributor.authorQi, Cancan
dc.contributor.authorGruzieva, Olena
dc.contributor.authorPage, Christian
dc.contributor.authorRezwan, Faisal I.
dc.date.accessioned2021-01-27T16:09:16Z
dc.date.available2021-01-27T16:09:16Z
dc.date.issued2020-11-25
dc.description.abstractBackground DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10−4; adolescence Penrichment = 2.10 × 10−7). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.en_UK
dc.identifier.citationVehmeijer FO, Küpers LK, Sharp GC., et al., (2020) DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome Medicine, Volume 12, Issue 1, 2020, Article number 105en_UK
dc.identifier.issn1756-994X
dc.identifier.urihttps://doi.org/10.1186/s13073-020-00810-w
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16268
dc.language.isoenen_UK
dc.publisherBioMed Centralen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEpigeneticsen_UK
dc.subjectDNA methylationen_UK
dc.subjectChildhood obesityen_UK
dc.subjectBody mass indexen_UK
dc.titleDNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studiesen_UK
dc.typeArticleen_UK

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
DNA_methylation_and_body_mass_index_from_birth_to_adolescence-2020.pdf
Size:
1.79 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Staff publications (SWEE)