Microbial exopolysaccharide composites in biomedicine and healthcare: trends and advances

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dc.contributor.authorAhuja, Vishal
dc.contributor.authorBhatt, Arvind Kumar
dc.contributor.authorBanu, J. Rajesh
dc.contributor.authorKumar, Vinod
dc.contributor.authorKumar, Gopalakrishnan
dc.contributor.authorYang, Yung-Hun
dc.contributor.authorBhatia, Shashi Kant
dc.date.accessioned2023-04-18T10:30:48Z
dc.date.available2023-04-18T10:30:48Z
dc.date.issued2023-04-06
dc.description.abstractMicrobial exopolysaccharides (EPSs), e.g., xanthan, dextran, gellan, curdlan, etc., have significant applications in several industries (pharma, food, textiles, petroleum, etc.) due to their biocompatibility, nontoxicity, and functional characteristics. However, biodegradability, poor cell adhesion, mineralization, and lower enzyme activity are some other factors that might hinder commercial applications in healthcare practices. Some EPSs lack biological activities that make them prone to degradation in ex vivo, as well as in vivo environments. The blending of EPSs with other natural and synthetic polymers can improve the structural, functional, and physiological characteristics, and make the composites suitable for a diverse range of applications. In comparison to EPS, composites have more mechanical strength, porosity, and stress-bearing capacity, along with a higher cell adhesion rate, and mineralization that is required for tissue engineering. Composites have a better possibility for biomedical and healthcare applications and are used for 2D and 3D scaffold fabrication, drug carrying and delivery, wound healing, tissue regeneration, and engineering. However, the commercialization of these products still needs in-depth research, considering commercial aspects such as stability within ex vivo and in vivo environments, the presence of biological fluids and enzymes, degradation profile, and interaction within living systems. The opportunities and potential applications are diverse, but more elaborative research is needed to address the challenges. In the current article, efforts have been made to summarize the recent advancements in applications of exopolysaccharide composites with natural and synthetic components, with special consideration of pharma and healthcare applications.en_UK
dc.identifier.citationAhuja V, Bhatt AK, Banu JR, et al., (2023) Microbial exopolysaccharide composites in biomedicine and healthcare: trends and advances. Polymers, Volume 15, Issue 7, April 2023, Article number 1801en_UK
dc.identifier.issn2073-4360
dc.identifier.urihttps://doi.org/10.3390/polym15071801
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/19498
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectbiopolymersen_UK
dc.subjectexopolysaccharidesen_UK
dc.subjectEPS compositesen_UK
dc.subjecthealthcareen_UK
dc.subjectfooden_UK
dc.titleMicrobial exopolysaccharide composites in biomedicine and healthcare: trends and advancesen_UK
dc.typeArticleen_UK

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