Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis

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dc.contributor.authorBrown, Samantha
dc.contributor.authorHigham, Thomas
dc.contributor.authorSlon, Viviane
dc.contributor.authorPääbo, Svante
dc.contributor.authorMeyer, Matthias
dc.contributor.authorDouka, Katerina
dc.contributor.authorBrock, Fiona
dc.contributor.authorComeskey, Daniel
dc.contributor.authorProcopio, Noemi
dc.contributor.authorShunkov, Michael
dc.contributor.authorDerevianko, Anatoly
dc.contributor.authorBuckley, Michael
dc.date.accessioned2023-10-23T12:33:57Z
dc.date.available2023-10-23T12:33:57Z
dc.date.issued2016-03-29
dc.description.abstractDNA sequencing has revolutionised our understanding of archaic humans during the Middle and Upper Palaeolithic. Unfortunately, while many Palaeolithic sites contain large numbers of bones, the majority of these lack the diagnostic features necessary for traditional morphological identification. As a result the recovery of Pleistocene-age human remains is extremely rare. To circumvent this problem we have applied a method of collagen fingerprinting to more than 2000 fragmented bones from the site of Denisova Cave, Russia, in order to facilitate the discovery of human remains. As a result of our analysis a single hominin bone (Denisova 11) was identified, supported through in-depth peptide sequencing analysis, and found to carry mitochondrial DNA of the Neandertal type. Subsequent radiocarbon dating revealed the bone to be >50,000 years old. Here we demonstrate the huge potential collagen fingerprinting has for identifying hominin remains in highly fragmentary archaeological assemblages, improving the resources available for wider studies into human evolution.en_UK
dc.identifier.citationBrown S, Higham T Slon V, et al., (2016) Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis, Scientific Reports, Volume 6, March 2016, Article Number 23559en_UK
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/srep23559
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/20427
dc.language.isoenen_UK
dc.publisherSpringer Natureen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectArchaeologyen_UK
dc.subjectMass spectrometryen_UK
dc.titleIdentification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysisen_UK
dc.typeArticleen_UK

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