Taurine alleviates Streptococcus uberis-induced inflammation by activating autophagy in mammary epithelial cells

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dc.contributor.authorWang, Zhenglei
dc.contributor.authorLan, Riguo
dc.contributor.authorXu, Yuanyuan
dc.contributor.authorZuo, Jiakun
dc.contributor.authorHan, Xiangan
dc.contributor.authorPhouthapane, Vanhnaseng
dc.contributor.authorLuo, Zhenhua
dc.contributor.authorMiao, Jinfeng
dc.date.accessioned2021-03-15T17:25:11Z
dc.date.available2021-03-15T17:25:11Z
dc.date.issued2021-03-12
dc.description.abstractStreptococcus uberis infection can cause serious inflammation and damage to mammary epithelial cells and tissues that can be significantly alleviated by taurine. Autophagy plays an important role in regulating immunity and clearing invasive pathogens and may be regulated by taurine. However, the relationships between taurine, autophagy, and S. uberis infection remain unclear. Herein, we demonstrate that taurine augments PTEN activity and inhibits Akt/mTOR signaling, which decreases phosphorylation of ULK1 and ATG13 by mTOR and activates autophagy. Activating autophagy accelerates the degradation of intracellular S. uberis, reduces intracellular bacterial load, inhibits over-activation of the NF-κB pathway, and alleviates the inflammation and damage caused by S. uberis infection. This study increases our understanding of the mechanism through which taurine regulates autophagy and is the first to demonstrate the role of autophagy in S. uberis infected MAC-T cells. Our study also provides a theoretical basis for employing nutritional elements (taurine) to regulate innate immunity and control S. uberis infection. It also provides theoretical support for the development of prophylactic strategies for this important pathogen.en_UK
dc.identifier.citationWang Z, Lan R, Xu Y, et al., (2021) Taurine alleviates Streptococcus uberis-induced inflammation by activating autophagy in mammary epithelial cells. Frontiers in Immunology, Volume 12, March 2021, Article number 631113en_UK
dc.identifier.issn1664-3224
dc.identifier.urihttps://doi.org/10.3389/fimmu.2021.631113
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16478
dc.language.isoenen_UK
dc.publisherFrontiersen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPTEN/Akt/mTOR signaling pathwayen_UK
dc.subjectAutophagyen_UK
dc.subjectTaurineen_UK
dc.subjectStreptococcus uberisen_UK
dc.subjectBovine Mastitisen_UK
dc.titleTaurine alleviates Streptococcus uberis-induced inflammation by activating autophagy in mammary epithelial cellsen_UK
dc.typeArticleen_UK

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