Detecting life on Mars and the life marker chip : antibody assays for detecting organic molecules in liquid extracts of Martian samples

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dc.contributor.advisorCullen, David C.
dc.contributor.authorRix, Catherine S.
dc.date.accessioned2012-06-19T10:58:37Z
dc.date.available2012-06-19T10:58:37Z
dc.date.issued2012-01
dc.description.abstractThe Life Marker Chip instrument, which has been selected to fly as part of the 2018 ExoMars rover mission payload, aims to detect up to 25 organic molecules in martian rocks and regolith, as markers of extant life, extinct life, meteoritic in-fall and spacecraft contamination. Martian samples will be extracted with a solvent and the resulting liquid extracts will be analysed using multiplexed microarray-format immunoassays. The LMC is under development by an international consortium led by the University of Leicester and the work described within this thesis was carried out at Cranfield University as part of the consortium’s broader program of work preparing the LMC instrument for flight in 2018. Within this thesis four specific areas of LMC instrument development are addressed: the investigation of immunoassay compatible liquid extraction solvents, the study of likely interactions of martian sample matrix with immunoassays, the development of antibodies for the detection of markers of extinct life and demonstration of solvent extraction and immunoassay detection in a flight representative format. Cont/d.en_UK
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/7250
dc.language.isoenen_UK
dc.publisherCranfield Universityen_UK
dc.rights© Cranfield University 2012. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright owneren_UK
dc.subjectAstrobiologyen_UK
dc.subjectExoMarsen_UK
dc.subjectextraction solventsen_UK
dc.subjectsample matrix effectsen_UK
dc.subjectrecombinant antibodiesen_UK
dc.subjectphage displayen_UK
dc.subjectmicrofluidicsen_UK
dc.titleDetecting life on Mars and the life marker chip : antibody assays for detecting organic molecules in liquid extracts of Martian samplesen_UK
dc.typeThesis or dissertationen_UK
dc.type.qualificationlevelDoctoralen_UK
dc.type.qualificationnamePhDen_UK

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PhD, EngD and MSc by research theses (Cranfield Health)