Paper microfluidic sentinel sensors enable rapid and on-site wastewater surveillance in community settings

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dc.contributor.authorPan, Yuwei
dc.contributor.authorWang, Baojun
dc.contributor.authorCooper, Jonathan M.
dc.contributor.authorYang, Zhugen
dc.date.accessioned2024-10-23T13:38:02Z
dc.date.available2024-10-23T13:38:02Z
dc.date.freetoread2024-10-23
dc.date.issued2024-10-16
dc.date.pubOnline2024-10-16
dc.description.abstractTracking genomic sequences as microbial biomarkers in wastewater has been used to determine community prevalence of infectious diseases, contributing to public health surveillance programs worldwide. Here, we report upon a low-cost, rapid, and user-friendly paper microfluidic platform for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza detection, using loop-mediated isothermal amplification, with signal read using a mobile phone camera. Sample-to-answer results were collected in less than 1.5 h, providing rapid multiplexed detection of viruses in wastewater, with a detection limit of <20 copies mL−1. The device was subsequently used for on-site testing of SARS-CoV-2 in wastewater samples from four quarantine hotels at London Heathrow Airport, showing comparable results to those obtained using polymerase chain reaction. This sensing platform, which enables rapid and localized testing without requiring samples to be sent to centralized laboratories, provides a potentially important public health tool for pandemic preparedness, with a variety of future wastewater surveillance applications in community settings.
dc.description.journalNameCell Reports Physical Science
dc.description.sponsorshipRoyal Academy of Engineering, Natural Environment Research Council, Leverhulme Trust
dc.identifier.citationPan Y, Wang B, Cooper JM, Yang Z. (2024) Paper microfluidic sentinel sensors enable rapid and on-site wastewater surveillance in community settings. Cell Reports Physical Science, Volume 5, Issue 10, October 2024, Article number 102154en_UK
dc.identifier.elementsID553902
dc.identifier.issn2666-3864
dc.identifier.issueNo10
dc.identifier.paperNo102154
dc.identifier.urihttps://doi.org/10.1016/j.xcrp.2024.102154
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23111
dc.identifier.volumeNo5
dc.languageEnglish
dc.language.isoen
dc.publisherElsevieren_UK
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S2666386424004399?via%3Dihub
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject40 Engineeringen_UK
dc.subject4016 Materials Engineeringen_UK
dc.subject4009 Electronics, Sensors and Digital Hardwareen_UK
dc.subjectInfectious Diseasesen_UK
dc.subjectPneumonia & Influenzaen_UK
dc.subjectBiotechnologyen_UK
dc.subjectBioengineeringen_UK
dc.subjectEmerging Infectious Diseasesen_UK
dc.subjectCoronavirusesen_UK
dc.subject4.1 Discovery and preclinical testing of markers and technologiesen_UK
dc.subjectInfectionen_UK
dc.subject3 Good Health and Well Beingen_UK
dc.subject3403 Macromolecular and materials chemistryen_UK
dc.titlePaper microfluidic sentinel sensors enable rapid and on-site wastewater surveillance in community settingsen_UK
dc.typeArticle
dcterms.dateAccepted2024-07-23

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