Effect of triptorelin on the protection from damage on mouse ovarian cells caused by tripterygium polyglycoside
| dc.contributor.author | Zhao Y-C | |
| dc.contributor.author | Zhao Y-F | |
| dc.date.accessioned | 2021-07-27T07:55:44Z | |
| dc.date.available | 2021-07-27T07:55:44Z | |
| dc.date.issued | 2021-04-15 | |
| dc.date.updated | 2021-05-12T11:14:39Z | |
| dc.description.abstract | To investigate the effect of triptorelin on the protection of tripterygium polyglycoside-induced damage to ovarian function on mouse ovarian cells through the study of Bcl-2 and Smac. Method: Thirty female SD mice with normal estrous cycle were selected and randomLy divided into three groups of 10 mice each. Group A (blank control group); Group B (tripterygium glycoside group); Group C (tripterygium glycoside + triptorelin group). For all three groups, the drug was stopped for 3 weeks and all mice were then sacrificed. Ovaries were taken to detect the expression of Bcl-2 and Smac in ovarian tissue. Results: Compared with the blank control group, the expression of Bcl-2 in the tripterygium polyglycoside group was reduced and the expression of Smac was enhanced, while for the triptorelin group, increased expression of Bcl-2 and decreased expression of Smac were observed with a statistical significance (P < 0.05). Conclusions: Tripterygium polyglycoside can cause damage to ovarian function in female mice; Triptorelin has a protective effect on tripterygium polyglycoside-induced damage to ovarian function in female mice. | en_UK |
| dc.identifier | https://doi.org/10.31083/j.ejgo.2021.02.2299 | |
| dc.identifier.citation | Zhao Y-C, Zhao Y-F. (2021) Effect of triptorelin on the protection from damage on mouse ovarian cells caused by tripterygium polyglycoside. European Journal of Gynaecological Oncology, Volume 42, Issue 2, April 2021 pp. 333-339 | en_UK |
| dc.identifier.issn | 0392-2936 | |
| dc.identifier.uri | https://doi.org/10.31083/j.ejgo.2021.02.2299 | |
| dc.identifier.uri | https://dspace.lib.cranfield.ac.uk/handle/1826/16937 | |
| dc.language.iso | en | en_UK |
| dc.publisher | I.R.O.G. Canada Inc. | en_UK |
| dc.rights | Attribution 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Triptorelin | en_UK |
| dc.subject | Tripterygium | en_UK |
| dc.subject | Ovarian function | en_UK |
| dc.subject | Bcl-2 | en_UK |
| dc.subject | Smac | en_UK |
| dc.title | Effect of triptorelin on the protection from damage on mouse ovarian cells caused by tripterygium polyglycoside | en_UK |
| dc.type | Article | en_UK |
| dcterms.dateAccepted | 2020-12-15 |