Recent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistry

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dc.contributor.authorKumar, Vinod
dc.contributor.authorKumar, Pankaj
dc.contributor.authorMaity, Sunil K.
dc.contributor.authorAgrawal, Deepti
dc.contributor.authorNarisetty, Vivek
dc.contributor.authorJacob, Samuel
dc.contributor.authorKumar, Gopalakrishnan
dc.contributor.authorBhatia, Shashi Kant
dc.contributor.authorKumar, Dinesh
dc.contributor.authorVivekanand, Vivekanand
dc.date.accessioned2024-06-03T11:29:22Z
dc.date.available2024-06-03T11:29:22Z
dc.date.issued2024-05-29
dc.description.abstractSuccinic acid (SA) is one of the top platform chemicals with huge applications in diverse sectors. The presence of two carboxylic acid groups on the terminal carbon atoms makes SA a highly functional molecule that can be derivatized into a wide range of products. The biological route for SA production is a cleaner, greener, and promising technological option with huge potential to sequester the potent greenhouse gas, carbon dioxide. The recycling of renewable carbon of biomass (an indirect form of CO2), along with fixing CO2 in the form of SA, offers a carbon-negative SA manufacturing route to reduce atmospheric CO2 load. These attractive attributes compel a paradigm shift from fossil-based to microbial SA manufacturing, as evidenced by several commercial-scale bio-SA production in the last decade. The current review article scrutinizes the existing knowledge and covers SA production by the most efficient SA producers, including several bacteria and yeast strains. The review starts with the biochemistry of the major pathways accumulating SA as an end product. It discusses the SA production from a variety of pure and crude renewable sources by native as well as engineered strains with details of pathway/metabolic, evolutionary, and process engineering approaches for enhancing TYP (titer, yield, and productivity) metrics. The review is then extended to recent progress on separation technologies to recover SA from fermentation broth. Thereafter, SA derivatization opportunities via chemo-catalysis are discussed for various high-value products, which are only a few steps away. The last two sections are devoted to the current scenario of industrial production of bio-SA and associated challenges, along with the author's perspective.en_UK
dc.identifier.citationKumar V, Kumar P, Maity SK, et al., (2024) Recent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistry. Biotechnology for Biofuels and Bioproducts, Volume 17, Issue 1, May 2024, Article number 72en_UK
dc.identifier.issn2731-3654
dc.identifier.urihttps://doi.org/10.1186/s13068-024-02508-2
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/21814
dc.language.isoen_UKen_UK
dc.publisherSpringer Natureen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSuccinic aciden_UK
dc.subjectBacteriaen_UK
dc.subjectYeasten_UK
dc.subjectDownstream processingen_UK
dc.subjectChemo-catalysisen_UK
dc.subjectCommercial playersen_UK
dc.subjectCircular bioeconomyen_UK
dc.titleRecent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistryen_UK
dc.typeArticleen_UK
dcterms.dateAccepted2024-04-20

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