Progress in hydroxyapatite-starch based sustainable biomaterials for biomedical bone substitution applications

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dc.contributor.authorMiculescu, F.
dc.contributor.authorMaidaniuc, A.
dc.contributor.authorVoicu, Stefan Ioan
dc.contributor.authorKumar Thakur, Vijay
dc.contributor.authorStan, G. E.
dc.contributor.authorCiocan, L. T.
dc.date.accessioned2017-09-18T13:38:43Z
dc.date.available2017-09-18T13:38:43Z
dc.date.issued2017-09-05
dc.description.abstractHydroxyapatite is a calcium phosphate intensively proposed as a bone substitution material because of its resemblance to the constituents of minerals present in natural bone. Since hydroxyapatite’s properties are mainly adequate for nonload bearing applications, different solutions are being tested for improving these properties and upgrading them near the target values of natural bone. On the other hand, starch (a natural and biodegradable polymer) and its blends with other polymers have been proposed as constituents in hydroxyapatite mixtures due to the adhesive, gelling, and swelling abilities of starch particles, useful in preparing well dispersed suspensions and consolidated ceramic bodies. This article presents the perspectives of incorporating starch and starch blends in hydroxyapatite materials. Based on the role of starch within the materials, the review covers its use as (i) a polymeric matrix in hydroxyapatite composites used as adhesives, bone cements, bone waxes, drug delivery devices or scaffolds and (ii) a sacrificial binder for fabrication of porous hydroxyapatite scaffolds. The suitability of these materials for bone reconstruction has becomes a reachable aim considering the recent advancements in ceramic fabrication and the current possibilities of controlling the processing parameters.en_UK
dc.identifier.citationMiculescu F, Maidaniuc A, Voicu SI, Thakur VK, Stan GE, Ciocan LT, Progress in hydroxyapatite-starch based sustainable biomaterials for biomedical bone substitution applications, ACS Sustainable Chemistry and Engineering, Volume 5, Issue 10, October 2017, pp8491-8512en_UK
dc.identifier.issn2168-0485
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/12505
dc.identifier.urihttp://dx.doi.org/10.1021/acssuschemeng.7b02314
dc.language.isoenen_UK
dc.publisherAmerican Chemical Societyen_UK
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectHydroxyapatiteen_UK
dc.subjectStarchen_UK
dc.subjectGelatinen_UK
dc.subjectChitosanen_UK
dc.subjectSilk fibroinen_UK
dc.subjectCellulose acetateen_UK
dc.subjectStarch blendsen_UK
dc.subjectStarch compositesen_UK
dc.subjectPorous ceramicsen_UK
dc.subjectScaffoldsen_UK
dc.subjectDrug-delivery systemsen_UK
dc.subjectBone cementsen_UK
dc.titleProgress in hydroxyapatite-starch based sustainable biomaterials for biomedical bone substitution applicationsen_UK
dc.typeArticleen_UK

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