A comparative study of three-dimensional printing directions: The degradation and toxicological profile of a PLA/PHA blend

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dc.contributor.authorGonzalez Ausejo, Jennifer
dc.contributor.authorRydz, Joanna
dc.contributor.authorMusioł, Marta
dc.contributor.authorSikorska, Wanda
dc.contributor.authorSobota, Michał
dc.contributor.authorWłodarczyk, Jakub
dc.contributor.authorAdamus, Grażyna
dc.contributor.authorJaneczek, Henryk
dc.contributor.authorKwiecień, Iwona
dc.contributor.authorHercog, Anna
dc.contributor.authorJohnston, Brian
dc.contributor.authorKhan, Habib R.
dc.contributor.authorKannappan, Vinodh
dc.contributor.authorJones, Keith R.
dc.contributor.authorMorris, Mark R.
dc.contributor.authorJiang, Gouzhan
dc.contributor.authorRadecka, Iza
dc.contributor.authorKowalczuk, Marek
dc.date.accessioned2018-07-03T11:38:33Z
dc.date.available2018-07-03T11:38:33Z
dc.date.issued2018-04-17
dc.description.abstractThe use of biobased plastics is of great importance for many applications. Blending thermoplastic polylactide (PLA) with polyhydroxyalkanoate (PHA) enables the formulation of a more mechanically powerful material and this enables tailored biodegradation properties. In this study we demonstrate the 3D printing of a PLA/PHA blend as a potential candidate for biocompatible material applications. The filament for 3D printing consisted of PHA, which contains predominantly 3-hydroxybutyrate units and a small amount of 3-hydroxyvalerate units, as revealed by multistage mass spectrometry (ESI-MSn). This research found that the properties of 3D printed species before and during abiotic degradation are dependent on printing orientation. Furthermore, the 3D printed specimens exhibited good biocompatibility with HEK293 cells, indicating real promise as biological scaffolds for tissue engineering applications.en_UK
dc.identifier.citationGonzalez-Ausejo J, Rydz J, Musioł M, Sikorska W, Sobota M, Włodarczyk J, Adamus G, Janeczek H, Kwiecień I, Hercog A, Johnston B, Khan HR, Kannappan V, Jones KR, Morris MR, Jiang G, Radecka I, Kowalczuk M, A comparative study of three-dimensional printing directions: The degradation and toxicological profile of a PLA/PHA blend, Polymer Degradation and Stability, Volume 152, June 2018, pp. 191-207en_UK
dc.identifier.issn0141-3910
dc.identifier.urihttp://dx.doi.org/10.1016/j.polymdegradstab.2018.04.024
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/13306
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectThree-dimensional printingen_UK
dc.subjectLayer orientationen_UK
dc.subjectDegradationen_UK
dc.subject(bio)degradable polyesteren_UK
dc.subjectToxicity testen_UK
dc.subjectCell proliferationen_UK
dc.titleA comparative study of three-dimensional printing directions: The degradation and toxicological profile of a PLA/PHA blenden_UK
dc.typeArticleen_UK

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