The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA)

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dc.contributor.authorBahmani, Ramin
dc.contributor.authorKim, DongGwan
dc.contributor.authorModareszadeh, Mahsa
dc.contributor.authorThompson, Andrew J.
dc.contributor.authorPark, Jeong Hoon
dc.contributor.authorYoo, Hye Hyun
dc.contributor.authorHwang, Seongbin
dc.date.accessioned2019-11-08T11:17:25Z
dc.date.available2019-11-08T11:17:25Z
dc.date.issued2019-11-04
dc.description.abstractBisphenol A (BPA) is a harmful environmental contaminant acting as an endocrine disruptor in animals, but it also affects growth and development in plants. Here, we have elucidated the functional mechanism of root growth inhibition by BPA in Arabidopsis thaliana using mutants, reporter lines and a pharmacological approach. In response to 10 ppm BPA, fresh weight and main root length were reduced, while auxin levels increased. BPA inhibited root growth by reducing root cell length in the elongation zone by suppressing expansin expression and by decreasing the length of the meristem zone by repressing cell division. The inhibition of cell elongation and cell division was attributed to the enhanced accumulation/redistribution of auxin in the elongation zone and meristem zone in response to BPA. Correspondingly, the expressions of most auxin biosynthesis and transporter genes were enhanced in roots by BPA. Taken together, it is assumed that the endocrine disruptor BPA inhibits primary root growth by inhibiting cell elongation and division through auxin accumulation/redistribution in Arabidopsis. This study will contribute to understanding how BPA affects growth and development in plants.en_UK
dc.identifier.citationBahmani R, Kim D, Modareszadeh M, et al., (2020) The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA). Environmental Pollution, Volume 257, February 2020, Article number 113516en_UK
dc.identifier.cris24968275
dc.identifier.issn0269-7491
dc.identifier.urihttps://doi.org/10.1016/j.envpol.2019.113516
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/14699
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAuxinen_UK
dc.subjectBisphenol Aen_UK
dc.subjectCell divisionen_UK
dc.subjectCell elongationen_UK
dc.subjectEthyleneen_UK
dc.subjectRooten_UK
dc.titleThe mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA)en_UK
dc.typeArticleen_UK

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