Campus source to sink wastewater surveillance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

dc.contributor.authorFolkes, Miles
dc.contributor.authorCastro-Gutierrez, V. M.
dc.contributor.authorLundy, Lian
dc.contributor.authorBajón-Fernández, Y.
dc.contributor.authorSoares, Ana
dc.contributor.authorJeffrey, Paul
dc.contributor.authorHassard, Francis
dc.date.accessioned2024-05-16T14:55:50Z
dc.date.available2024-05-16T14:55:50Z
dc.date.issued2024-05-06
dc.description.abstractWastewater-based surveillance (WBS) offers an aggregate, and cost-effective approach for tracking infectious disease outbreak prevalence within communities, that provides data on community health complementary to individual clinical testing. This study reports on a 16-month WBS initiative on a university campus in England, UK, assessing the presence of SARS-CoV-2 in sewers from large buildings, downstream sewer locations, raw wastewater, partially treated and treated effluents. Key findings include the detection of the Alpha (B.1.1.7) variant in wastewater, with 70 % of confirmed campus cases correlating with positive wastewater samples. Notably, ammonium nitrogen (NH4-N) levels showed a positive correlation (ρ = 0.543, p < 0.01) with virus levels at the large building scale, a relationship not observed at the sewer or wastewater treatment works (WWTW) levels due to dilution. The WWTW was compliant to wastewater standards, but the secondary treatment processes were not efficient for virus removal as SARS-CoV-2 was consistently detected in treated discharges. Tools developed through WBS can also be used to enhance traditional environmental monitoring of aquatic systems. This study provides a detailed source-to-sink evaluation, emphasizing the critical need for the widespread application and improvement of WBS. It showcases WBS utility and reinforces the ongoing challenges posed by viruses to receiving water quality.en_UK
dc.identifier.citationFolkes M, Castro-Gutierrez VM, Lundy L, et al., (2024) Campus source to sink wastewater surveillance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Current Research in Microbial Sciences, Volume 6, 2024, Article number100240en_UK
dc.identifier.issn2666-5174
dc.identifier.urihttps://doi.org/10.1016/j.crmicr.2024.100240
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/21638
dc.language.isoen_UKen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectWastewater surveillanceen_UK
dc.subjectWastewater-based surveillance (WBS)en_UK
dc.subjectWastewater-based epidemiology (WBE)en_UK
dc.subjectSurveillance COVID-19en_UK
dc.subjectSARS-CoV-2en_UK
dc.subjectCoronavirusen_UK
dc.subjectPepper mild mottle virus (PMMoV)en_UK
dc.titleCampus source to sink wastewater surveillance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)en_UK
dc.typeArticleen_UK

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