Polyhydroxyalkanoates synthesis using acidogenic fermentative effluents

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dc.contributor.authorBanu, J. Rajesh
dc.contributor.authorGinni, G.
dc.contributor.authorKavitha, S.
dc.contributor.authorKannah, R. Yukesh
dc.contributor.authorKumar, Vinod
dc.contributor.authorKumar, S. Adish
dc.contributor.authorGunasekaran, M.
dc.contributor.authorTyagi, Vinay Kumar
dc.contributor.authorKumar, Gopalakrishnan
dc.date.accessioned2021-11-19T10:21:01Z
dc.date.available2021-11-19T10:21:01Z
dc.date.issued2021-11-11
dc.description.abstractPolyhydroxyalkanoates (PHA) are natural polyesters synthesized by microbes which consume excess amount of carbon and less amount of nutrients. It is biodegradable in nature, and it synthesized from renewable resources. It is considered as a future polymer, which act as an attractive replacement to petrochemical based polymers. The main hindrance to the commercial application of PHA is the high manufacturing cost. This article provides an overview of different cost-effective substrates, their characteristics and composition, major strains involved in economical production of PHA and biosynthetic pathways leading to accumulation of PHA. This review also covers the operational parameters, various fermentative modes including batch, fed-batch, repeated fed-batch and continuous fed-batch systems, along with advanced feeding strategies such as single pulse carbon feeding, feed forward control, intermittent carbon feeding, feast famine conditions to observe their effects for improving PHA synthesis and associated challenges. In addition, it also presents the economic analysis and future perspectives for the commercialization of PHA production process thereby making the process sustainable and lucrative with the possibility of commercial biomanufacturing.en_UK
dc.identifier.citationBanu JR, Ginni G, Kavitha S,et al., (2021) Polyhydroxyalkanoates synthesis using acidogenic fermentative effluents. International Journal of Biological Macromolecules, Volume 193, Part B, December 2021, pp. 2079-2092en_UK
dc.identifier.issn0141-8130
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.11.040
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/17282
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPHAen_UK
dc.subjectBiosynthetic pathwaysen_UK
dc.subjectFermentative modesen_UK
dc.titlePolyhydroxyalkanoates synthesis using acidogenic fermentative effluentsen_UK
dc.typeArticleen_UK

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