Ultra-high-resolution time-frequency analysis of EEG to characterise brain functional connectivity with the application in Alzheimer's disease

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dc.contributor.authorCao, Jun
dc.contributor.authorZhao, Yifan
dc.contributor.authorShan, Xiaocai
dc.contributor.authorBlackburn, Daniel
dc.contributor.authorWei, Jize
dc.contributor.authorErkoyuncu, John Ahmet
dc.contributor.authorChen, Liangyu
dc.contributor.authorSarrigiannis, Ptolemaios G.
dc.date.accessioned2022-08-18T13:50:25Z
dc.date.available2022-08-18T13:50:25Z
dc.date.issued2022-08-11
dc.description.abstractObjective. This study aims to explore the potential of high-resolution brain functional connectivity based on electroencephalogram, a non-invasive low-cost technique, to be translated into a long-overdue biomarker and a diagnostic method for Alzheimer's disease (AD). Approach. The paper proposes a novel ultra-high-resolution time-frequency nonlinear cross-spectrum method to construct a promising biomarker of AD pathophysiology. Specifically, using the peak frequency estimated from a revised Hilbert–Huang transformation (RHHT) cross-spectrum as a biomarker, the support vector machine classifier is used to distinguish AD from healthy controls (HCs). Main results. With the combinations of the proposed biomarker and machine learning, we achieved a promising accuracy of 89%. The proposed method performs better than the wavelet cross-spectrum and other functional connectivity measures in the temporal or frequency domain, particularly in the Full, Delta and Alpha bands. Besides, a novel visualisation approach developed from topography is introduced to represent the brain functional connectivity, with which the difference between AD and HCs can be clearly displayed. The interconnections between posterior and other brain regions are obviously affected in AD. Significance. Those findings imply that the proposed RHHT approach could better track dynamic and nonlinear functional connectivity information, paving the way for the development of a novel diagnostic approach.en_UK
dc.identifier.citationCao J, Zhao Y, Shan X, et al., (2022) Ultra-high-resolution time-frequency analysis of EEG to characterise brain functional connectivity with the application in Alzheimer's disease. Journal of Neural Engineering, Volume 19, Issue 4, August 2022, Article number 046034en_UK
dc.identifier.issn1741-2560
dc.identifier.urihttps://doi.org/10.1088/1741-2552/ac84ac
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/18331
dc.language.isoenen_UK
dc.publisherIOP Publishingen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectelectroencephalogram (EEG)en_UK
dc.subjectRevised Hilbert-Huang Transformation (RHHT)en_UK
dc.subjectpeak frequency of cross-spectrum (PFoCS)en_UK
dc.subjectSupport Vector Machine (SVM)en_UK
dc.subjecttopographic visualisationen_UK
dc.titleUltra-high-resolution time-frequency analysis of EEG to characterise brain functional connectivity with the application in Alzheimer's diseaseen_UK
dc.typeArticleen_UK

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