Design and fabrication of a three-dimensional microfluidic device for blood separation using micro-injection moulding

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dc.contributor.authorAttia, Usama M.
dc.contributor.authorMarson, Silvia
dc.contributor.authorAlcock, Jeffrey R.
dc.date.accessioned2017-03-06T09:00:40Z
dc.date.available2017-03-06T09:00:40Z
dc.date.issued2013-12-03
dc.description.abstractMicro-manufacturing is a fast developing area due to the increasing demand for components and systems of high precision and small dimensions. A number of challenges are yet to be overcome before the full potential of such techniques is realised. Examples of such challenges include limitations in component geometry, material selection and suitability for mass production. Some micro-manufacturing techniques are still at early development stages, while other techniques are at higher stage of manufacturing readiness level but require adaptation in part design or manufacturing procedure to overcome such limitations. This article presents a case study, where the design of a micro-scale, biomedical device is adapted for functionality and manufacturability by a high-volume micro-fabrication technique. Investigations are described towards a disposable three-dimensional, polymer-based device for the separation of blood cells and plasma. The importance of attempting a three-dimensional device design and fabrication route was to take advantage of the highthroughput per unit volume that such systems can, in principle, allow. The importance of a micro-moulding fabrication route was to allow such blood-containing devices to be cheaply manufactured for disposability. Initial device tests showed separation efficiency up to approximately 80% with diluted blood samples. The produced prototype indicated that the process flow was suitable for high-volume fabrication of three-dimensional microfluidics.en_UK
dc.identifier.citationUsama M Attia, Silvia Marson and Jeffrey R Alcock. Design and fabrication of a three-dimensional microfluidic device for blood separation using micro-injection moulding. Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, June 2014, Vol 228, Issue 6, 2014, pp941-949en_UK
dc.identifier.issn0954-4054
dc.identifier.urihttp://dx.doi.org/10.1177/0954405413510153
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/11565
dc.language.isoenen_UK
dc.publisherSageen_UK
dc.rightsAttribution-Non-Commercial 3.0 Unported (CC BY-NC 3.0) You are free to: Share — copy and redistribute the material in any medium or format, Adapt — remix, transform, and build upon the material. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Information: Non-Commercial — You may not use the material for commercial purposes. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
dc.subjectMicrofluidics designen_UK
dc.subjectmicro-manufacturingen_UK
dc.subjectthree-dimensionalen_UK
dc.subjectblood separationen_UK
dc.subjectlaminationen_UK
dc.subjectmicro-injection mouldingen_UK
dc.titleDesign and fabrication of a three-dimensional microfluidic device for blood separation using micro-injection mouldingen_UK
dc.typeArticleen_UK

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