Nanomaterial-based aptamer sensors for analysis of illicit drugs and evaluation of drugs consumption for wastewater-based epidemiology

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dc.contributor.authorMao, Kang
dc.contributor.authorZhang, Hua
dc.contributor.authorPan, Yuwei
dc.contributor.authorZhang, Kuankuan
dc.contributor.authorCao, Haorui
dc.contributor.authorLi, Xiqing
dc.contributor.authorYang, Zhugen
dc.date.accessioned2020-07-07T11:12:50Z
dc.date.available2020-07-07T11:12:50Z
dc.date.issued2020-06-06
dc.description.abstractThe abuse of illicit drugs usually associated with dramatic crimes may cause significant problems for the whole society. Wastewater-based epidemiology (WBE) has been demonstrated to be a novel and cost-effective way to evaluate the abuse of illicit drugs at the community level, and has been used as a routine method for monitoring and played a significant role for combating the crimes in some countries, e.g. China. The method can also provide temporal and spatial variation of drugs of abuse. The detection methods mainly remain on the conventional liquid chromatography coupled with mass spectrometry, which is extremely sensitive and selective, however needs advanced facility and well-trained personals, thus limit it in the lab. As an alternative, sensors have emerged to be a powerful analytical tool for a wide spectrum of analytes, in particular aptamer sensors (aptasensors) have attracted increasing attention and could act as an efficient tool in this field due to the excellent characteristics of selectivity, sensitivity, low cost, miniaturization, easy-to-use, and automation. In this review, we will briefly introduce the context, specific assessment process and applications of WBE and the recent progress of illicit drug aptasensors, in particular focusing on optical and electrochemical sensors. We then highlight several recent aptasensors for illicit drugs in new technology integration and discuss the feasibility of these aptasensor for WBE. We will summarize the challenges and propose our insights and opportunity on aptasensor for WBE to evaluate community-wide drug use trends and public healthen_UK
dc.identifier.citationMao K, Zhang H, Pan Y, et al., (2020) Nanomaterial-based aptamer sensors for analysis of illicit drugs and evaluation of drugs consumption for wastewater-based epidemiology. TrAC Trends In Analytical Chemistry, Volume 130, September 2020, Article number 115975en_UK
dc.identifier.issn0165-9936
dc.identifier.urihttps://doi.org/10.1016/j.trac.2020.115975
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/15527
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdevice integrationen_UK
dc.subjectDNAen_UK
dc.subjectnanomaterialen_UK
dc.subjectwastewater-based epidemiologyen_UK
dc.subjectaptasensoren_UK
dc.subjectIllicit drugsen_UK
dc.titleNanomaterial-based aptamer sensors for analysis of illicit drugs and evaluation of drugs consumption for wastewater-based epidemiologyen_UK
dc.typeArticleen_UK

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