Synthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification.

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dc.contributor.authorMalik, D. J.
dc.contributor.authorWebb, C.
dc.contributor.authorHoldich, R. G.
dc.contributor.authorRamsden, Jeremy J.
dc.contributor.authorWarwick, G. L.
dc.contributor.authorRoche, I.
dc.contributor.authorWilliams, D. J.
dc.contributor.authorTrochimczuk, A. W.
dc.contributor.authorDale, J. A.
dc.contributor.authorHoenich, N. A.
dc.date.accessioned2009-05-11T13:38:32Z
dc.date.available2009-05-11T13:38:32Z
dc.date.issued2009-05-07
dc.description.abstractCrosslinked polystyrene co-divinylbenzene adsorbent microspheres with median diameters between 40 and 300 μm, with an enhanced proportion of mesopores in the range 4–10 nm, have been synthesized using a membrane emulsification technique. The aim was to develop an adsorbent for the selective removal of middle molecular weight uraemic toxins (size range 0.5–20 kDa), e.g. β2-microglobulin (11.8 kDa), whilst size-excluding larger blood proteins, e.g. serum albumin (MW 69 kDa). Using inverse size exclusion chromatography, the role of size exclusion has been demonstrated using hen egg lysozyme (a surrogate for β2-microglobulin) and human serum albumin as model proteins for batch adsorption studies. The adsorbent sample possessing a nanoporous structure with pores predominantly smaller than 10 nm successfully size-excludes serum albumin whilst displaying significant adsorption capacity for the middle molecular weight lysozyme (14.3 kDa).en_UK
dc.identifier.citationD.J. Malik, C. Webb, R.G. Holdich, J.J. Ramsden, G.L. Warwick, I. Roche, D.J. Williams, A.W. Trochimczuk, J.A. Dale, N.A. Hoenich, Synthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification, Separation and Purification Technology, Volume 66, Issue 3, 7 May 2009, Pages 578-585en_UK
dc.identifier.issn1383-5866
dc.identifier.urihttp://dx.doi.org/10.1016/j.seppur.2009.01.016
dc.identifier.urihttp://hdl.handle.net/1826/3391
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.subjectMiddle molecular weight toxinsen_UK
dc.subjectHaemoadsorptionen_UK
dc.subjectInverse size exclusion chromatographyen_UK
dc.subjectHaemodialysisen_UK
dc.subjectMicrospheresen_UK
dc.subjectMembrane emulsificationen_UK
dc.titleSynthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification.en_UK
dc.typePostprinten_UK

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