Encapsulation of cancer therapeutic agent dacarbazine using nanostructured lipid carrier

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dc.contributor.authorAlmoussalam, Musallam
dc.contributor.authorZhu, Huijun
dc.date.accessioned2016-08-11T18:42:47Z
dc.date.available2016-08-11T18:42:47Z
dc.date.issued2016-04-26
dc.description.abstractThe only formula of dacarbazine (Dac) in clinical use is intravenous infusion, presenting a poor therapeutic profile due to the low dispersity of the drug in aqueous solution To overcome this, a nanostructured lipid carrier (NLC) consisting of glyceryl palmitostearate and isopropyl myristate was developed to encapsulate Dac. NLCs with controlled size were achieved using high shear dispersion (HSD) following solidification of oil-in-water emulsion. The synthesis parameters, including surfactant concentration, the speed and time of HSD were optimized to achieve the smallest NLC with size, polydispersion index and zeta potential of 155 ± 10 nm, 0.2 ± 0.01, and -43.4 ± 2 mV, respectively. The optimal parameters were also employed for Dac-loaded NLC preparation. The resultant NLC loaded with Dac possessed size, polydispersion index and zeta potential of 190 ± 10 nm, 0.2 ± 0.01, and -43.5 ± 1.2 mV, respectively. The drug encapsulation efficiency and drug loading reached 98% and 14%, respectively. This is the first report on encapsulation of Dac using NLC, implying that NLC could be a new potential candidate as drug carrier to improve the therapeutic profile of Dac.en_UK
dc.identifier.citationAlmoussalam, M, Zhu, H. (2016) Encapsulation of cancer therapeutic agent dacarbazine using nanostructured lipid carrier, 110, e53760en_UK
dc.identifier.issn1940-087X
dc.identifier.urihttp://dx.doi.org/10.3791/53760
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/10282
dc.language.isoenen_UK
dc.publisherJOVEen_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNanostructured lipid carrieren_UK
dc.subjectNLCen_UK
dc.subjectDacarbazineen_UK
dc.subjectDACen_UK
dc.subjectHigh shear dispersionen_UK
dc.subjectHSDen_UK
dc.subjectDrug deliveryen_UK
dc.titleEncapsulation of cancer therapeutic agent dacarbazine using nanostructured lipid carrieren_UK
dc.typeArticleen_UK

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