The interplay between BMU activity linked to mechanical stress, specific surface and inhibitory theory dictate bone mass distribution: predictions from a 3D computational model

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dc.contributor.authorBerli, Marcelo
dc.contributor.authorFranco, Feliciano
dc.contributor.authorDi Paolo, José
dc.contributor.authorZioupos, Peter
dc.contributor.authorBorau, Carlos
dc.date.accessioned2022-08-04T15:37:54Z
dc.date.available2022-08-04T15:37:54Z
dc.date.issued2022-07-30
dc.description.abstractBone mechanical and biological properties are closely linked to its internal tissue composition and mass distribution, which are in turn governed by the purposeful action of the basic multicellular units (BMUs). The orchestrated action of osteoclasts and osteoblasts, the resorbing and forming tissue cells respectively, in BMUs is responsible for tissue maintenance, repair and adaptation to changing load demands through the phenomenon known as remodelling. In this work, a computational mechano-biological model of bone remodelling based on the inhibitory theory and a new scheme of bone resorption introduced previously in a 2D model, is extended to a 3D model of the real external geometry of a femur under normal walking loads. Starting from a uniform apparent density (ratio of tissue local mass to total local volume) distribution, the BMU action can be shown to lead naturally to an internal density distribution similar to that of a real bone, provided that the initial density value is high enough to avoid unrealistic final mass deposition in zones of high energy density and excessive damage. Physiological internal density values are reached throughout the whole 3D geometry, and at the same time a ‘boomerang’-like relationship between apparent and material density (ratio of tissue mass to tissue volume) emerges naturally under the proposed remodelling scheme. It is also shown here that bone-specific surface is a key parameter that determines the intensity of BMU action linked to the mechanical and biological requirements. Finally, by engaging in simulations of bone in disuse, we were able to confirm the appropriate selection of the model parameters. As an example, our results show good agreement with experimental measurements of bone mass on astronauts a fact that strengthens our belief in the insightful nature of our novel 3D computational model.en_UK
dc.identifier.citationBerli ME, Franco F, Di Paolo J, et al., (2022) The interplay between BMU activity linked to mechanical stress, specific surface and inhibitory theory dictate bone mass distribution: predictions from a 3D computational model. Computers in Biology and Medicine, Volume 148, September 2022, Article number 105898en_UK
dc.identifier.issn0010-4825
dc.identifier.urihttps://doi.org/10.1016/j.compbiomed.2022.105898
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/18283
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBone remodellingen_UK
dc.subjectfinite elementen_UK
dc.subjectBMUen_UK
dc.subjectbone densityen_UK
dc.subjectspecific surfaceen_UK
dc.titleThe interplay between BMU activity linked to mechanical stress, specific surface and inhibitory theory dictate bone mass distribution: predictions from a 3D computational modelen_UK
dc.typeArticleen_UK

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