Cellulose acetate membranes functionalized with resveratrol by covalent immobilization for improved osseointegration

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dc.contributor.authorPandele, A. M.
dc.contributor.authorNeacsu, P.
dc.contributor.authorCimpean, A.
dc.contributor.authorStaras, A. I.
dc.contributor.authorMiculescu, F.
dc.contributor.authorIordache, A.
dc.contributor.authorVoicu, S. I.
dc.contributor.authorThakur, Vijay Kumar
dc.contributor.authorToader, O. D.
dc.date.accessioned2018-11-14T10:24:48Z
dc.date.available2018-11-14T10:24:48Z
dc.date.issued2018-11-13
dc.description.abstractCovalent immobilization of resveratrol onto cellulose acetate polymeric membranes used as coating on a Mg-1Ca-0.2Mn-0.6Zr alloy is presented for potential application in the improvement of osseointegration processes. For this purpose, cellulose acetate membrane is hydrolysed in the presence of potassium hydroxide, followed by covalent immobilization of aminopropyl triethoxy silane. Resveratrol was immobilized onto membranes using glutaraldehyde as linker. The newly synthesised functional membranes were thoroughly characterized for their structural characteristics determination employing X-ray photoelectron spectroscopy (XPS), infrared spectroscopy (FT-IR), Raman spectroscopy, thermogravimetric analysis (TGA/DTG) and scanning electron microscopy (SEM) techniques. Subsequently, in vitro cellular tests were performed for evaluating the cytotoxicity biocompatibility of synthesized materials and also the osseointegration potential of obtained derivatised membrane material. It was demonstrated that both polymeric membranes support viability and proliferation of the pre-osteoblastic MC3T3-E1 cells, thus providing a good protection against the potential harmful effects of the compounds released from coated alloys. Furthermore, cellulose acetate membrane functionalized with resveratrol exhibits a significant increase in alkaline phosphatase activity and extracellular matrix mineralization, suggesting its suitability to function as an implant surface coating for guided bone regeneration.en_UK
dc.identifier.citationPandele AM, Neacsu P, Cimpean A, et al., Cellulose acetate membranes functionalized with resveratrol by covalent immobilization for improved osseointegration. Applied Surface Science, Volume 438, 30 April 2018, pp. 2-13en_UK
dc.identifier.issn0169-4332
dc.identifier.urihttps://doi.org/10.1016/j.apsusc.2017.11.102
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/13636
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCellulose acetate membranesen_UK
dc.subjectDerivatizationen_UK
dc.subjectOsseointegrationen_UK
dc.subjectResveratrolen_UK
dc.titleCellulose acetate membranes functionalized with resveratrol by covalent immobilization for improved osseointegrationen_UK
dc.typeArticleen_UK

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