Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract

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dc.contributor.authorRusso, Flavia
dc.contributor.authorBoghi, Andrea
dc.contributor.authorGori, Fabio
dc.date.accessioned2018-01-04T17:54:53Z
dc.date.available2018-01-04T17:54:53Z
dc.date.issued2017-12-02
dc.description.abstractMagnetic nano drug targeting, with an external magnetic field, can potentially improve the drug absorption in specific locations of the body. However, the effectiveness of the procedure can be reduced due to the limitations of the magnetic field intensity. This work investigates this technique with the Computational Fluid Dynamics (CFD) approach. A single rectangular coil generates the external magnetic field. A patient-specific geometry of the Trachea, with its primary and secondary bronchi, is reconstructed from Digital Imaging and Communications in Medicine (DICOM) formatted images, throughout the Vascular Modelling Tool Kit (VMTK) software. A solver, coupling the Lagrangian dynamics of the magnetic nanoparticles with the Eulerian dynamics of the air, is used to perform the simulations. The resistive pressure, the pulsatile inlet velocity and the rectangular coil magnetic field are the boundary conditions. The dynamics of the injected particles is investigated without and with the magnetic probe. The flow field promotes particles adhesion to the tracheal wall. The particles volumetric flow rate in both cases has been calculated. The magnetic probe is shown to increase the particles flow in the target region, but at a limited extent. This behavior has been attributed to the small particle size and the probe configuration.en_UK
dc.identifier.citationRusso F, Boghi A, Gori F. (2018) Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract. Journal of Magnetism and Magnetic Materials, Volume 451, April 2018, pp. 554-564en_UK
dc.identifier.issn0304-8853
dc.identifier.urihttps://doi.org/10.1016/j.jmmm.2017.11.118
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/12845
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMagnetic hydro dynamicsen_UK
dc.subjectPatient-specificen_UK
dc.subjectNanoparticlesen_UK
dc.subjectLagrangian modelen_UK
dc.subjectEulerian modelen_UK
dc.subjectLower respiratory tracten_UK
dc.titleNumerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tracten_UK
dc.typeArticleen_UK

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