Protection versus pathology in aviremic and high viral load HIV-2 infection—The pivotal role of immune activation and T-cell kinetics
dc.contributor.author | Hegedus, Andrea | |
dc.contributor.author | Nyamweya, Samuel | |
dc.contributor.author | Zhang, Yan | |
dc.contributor.author | Govind, Sheila | |
dc.contributor.author | Aspinall, Richard | |
dc.contributor.author | Mashanova, Alla | |
dc.contributor.author | Jansen, Vincent A. A. | |
dc.contributor.author | Whittle, Hilton | |
dc.contributor.author | Jaye, Assan | |
dc.contributor.author | Flanagan, Katie L. | |
dc.contributor.author | Macallan, Derek C. | |
dc.date.accessioned | 2016-02-17T16:40:28Z | |
dc.date.available | 2016-02-17T16:40:28Z | |
dc.date.issued | 2014-05-05 | |
dc.description.abstract | Background. Many human immunodeficiency virus (HIV)–2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status. Methods. We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance. Results. Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV (P < .01 for all cell types). A similar trend was observed in the pattern of in vivo turnover of memory CD4+ and CD8+ T-cells and TREC depletion in naive CD4+ T-cells, although naive T-cell turnover was relatively unaffected by either infection. T-cell turnover, immune activation, and progressor status were closely associated. Conclusions. HIV-2 non-progressors have low rates of T-cell turnover (both CD4+ and CD8+) and minimal immune activation; high viral load HIV-2 progressors had high values, similar to or exceeding those in HIV-1 infection. | en_UK |
dc.identifier.citation | Hegedus A, Nyamweya S, Zhang Y, et al., (2014) Protection versus pathology in aviremic and high viral load HIV-2 infection—The pivotal role of immune activation and T-cell kinetics. Journal of Infectious Diseases, Volume 210, Issue 5, September 2014, pp. 752-761 | en_UK |
dc.identifier.issn | 0022-1899 | |
dc.identifier.uri | http://dx.doi.org/10.1093/infdis/jiu165 | |
dc.identifier.uri | https://dspace.lib.cranfield.ac.uk/handle/1826/9703 | |
dc.language.iso | en | en_UK |
dc.publisher | University of Chicago Press / Oxford University Press | en_UK |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | CD4 | en_UK |
dc.subject | CD8 | en_UK |
dc.subject | HIV-2 | en_UK |
dc.subject | HIV-1 | en_UK |
dc.subject | HIV pathogenesis | en_UK |
dc.subject | immune activation | en_UK |
dc.subject | immune memory | en_UK |
dc.subject | T-cell | en_UK |
dc.title | Protection versus pathology in aviremic and high viral load HIV-2 infection—The pivotal role of immune activation and T-cell kinetics | en_UK |
dc.type | Article | en_UK |
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